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chilblain lupus (CHLE) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

chilblain lupus

MONDO:0019557

Also known as:CHLEHutchinson lupus

Overview

A rare, chronic cutaneous lupus erythematosus disease characterized by red or violaceous, initially pruritic (evolving to painful) papules and plaques located on acral areas (especially dorsal aspects of fingers and toes, while the nose and ear involvement is uncommon), exacerbated by cold and damp conditions, with fissuring and ulceration occasionally observed. Coexistence of discoid lupus erythematosus lesions elsewhere on the body and occasional progression to systemic lupus erythematosus may be associated. Histological examination and direct immunofluorescence studies reveal nonspecific inflammatory lupus erythematosus changes while results of cryoglobulin and cold agglutinin studies are negative.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for chilblain lupus.

35 publications have been identified in PubMed for chilblain lupus. Research spans Case Report / Case Series (48%), Basic Science / Preclinical (26%), and Review / Meta-Analysis (16%).

Research Type	Count	% of Total
Patient case studies	15	48%

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:46 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:90280

GARD

Genetic and Rare Diseases Info Center

GARD:19130

Questions for Your Care Team

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chilblain lupus

Overview

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

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Questions for Your Care Team

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