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childhood absence epilepsy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

childhood absence epilepsy

MONDO:0010826

Also known as:early onset absence epilepsypyknolepsyabsence seizure

Find Clinical TrialsTrials

Overview

A familial generalized pediatric epilepsy, characterized by very frequent (multiple per day) absence seizures, usually occurring in children between the ages of 4 and 10 years, with, in most cases, a good prognosis.

Treatments1 FDA approved

Clinical Trials3 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for childhood absence epilepsy has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for childhood absence epilepsy, including ETHOSUXIMIDE (ZARONTIN, approved 1960). An additional 3 compounds hold orphan drug designation.

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 3 PHASE3. Research is sponsored by a mix of industry and academic institutions.

127 publications have been identified in PubMed for childhood absence epilepsy. Research spans Basic Science / Preclinical (42%), Epidemiology / Natural History (14%), and Diagnostic / Biomarker (9%).

Research Type	Count	% of Total
Laboratory research	53

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 7:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:64280

GARD

Genetic and Rare Diseases Info Center

GARD:16667

Questions for Your Care Team

→What are the benefits and potential side effects of ZARONTIN for managing childhood absence epilepsy?
→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Brand Name	Generic Name	Sponsor	Designated	Exclusivity End	Designation Status
flunarizine	flunarizine	Xenon Pharmaceuticals Inc.	2021	—	Designated
brivaracetam	brivaracetam	UCB, Inc.	2019	—	Designated
cannabidiol	cannabidiol	Benuvia Operations LLC	2019	—	Designated

Kisho

childhood absence epilepsy

Overview

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Orphan Drug Designations

Clinical Trials

Recent Publications

childhood absence epilepsy

Overview

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Orphan Drug Designations

Clinical Trials

Recent Publications