GABRG2 encodes gamma-aminobutyric acid type A receptor subunit gamma2 (475 aa). Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. Highest expression in Brain Cerebellar Hemisphere (20.3 TPM) and Brain Frontal Cortex BA9 (19.4 TPM).

Febrile seizures, familial, 8 is associated with mutations in the GABRG2 gene on chromosome 5.

GABRG2 is classified as a druggable target (Druggable Genome and Ion Channel categories) with score 0.4.

Genetic testing for GABRG2 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for febrile seizures, familial, 8 has been reported in the published literature.

Phenotype severity distribution: 1 very common feature, 1 common feature.

No clinical trials have been registered for febrile seizures, familial, 8.

29 publications have been identified in PubMed for febrile seizures, familial, 8. Research spans Epidemiology / Natural History (52%), Basic Science / Preclinical (21%), and Review / Meta-Analysis (10%).

Recent Publications

• Sadık ZZT (2026). [PMID: 41804790](https://pubmed.ncbi.nlm.nih.gov/41804790/). *Journal of paediatrics and child health*. [Epidemiology / Natural History]

• Ong JJ (2026). [PMID: 41617503](https://pubmed.ncbi.nlm.nih.gov/41617503/). *The Medical journal of Malaysia*. [Epidemiology / Natural History]

• Yavuz M (2026). [PMID: 41570404](https://pubmed.ncbi.nlm.nih.gov/41570404/). *Brain & development*. [Case Report / Case Series]

• Song HY (2026). [PMID: 42270290](https://pubmed.ncbi.nlm.nih.gov/42270290/). *BMJ Paediatr Open*. [Epidemiology / Natural History]

• Klakk J (2026). [PMID: 41564577](https://pubmed.ncbi.nlm.nih.gov/41564577/). *Epilepsy & behavior : E&B*. [Epidemiology / Natural History]

• Mungklang N (2026). [PMID: 42172817](https://pubmed.ncbi.nlm.nih.gov/42172817/). *Brain Dev*. [Epidemiology / Natural History]

• Bui AH (2026). [PMID: 41840878](https://pubmed.ncbi.nlm.nih.gov/41840878/). *Pediatrics international : official journal of the Japan Pediatric Society*. [Epidemiology / Natural History]

• Mohamed Z (2026). [PMID: 42005082](https://pubmed.ncbi.nlm.nih.gov/42005082/). *Avicenna J Med*. [Epidemiology / Natural History]

• Bui AH (2026). [PMID: 41409019](https://pubmed.ncbi.nlm.nih.gov/41409019/). *Epilepsia open*. [Epidemiology / Natural History]

• Güleç A (2026). [PMID: 42049252](https://pubmed.ncbi.nlm.nih.gov/42049252/). *Int J Dev Neurosci*. [Basic Science / Preclinical]