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generalized epilepsy with febrile seizures plus, type 4 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

generalized epilepsy with febrile seizures plus, type 4

MONDO:0012346

Also known as:GEFSP4Gefs+, type 4

Overview

GeneticsAutosomal dominant

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Bilateral tonic-clonic seizure and Febrile seizure (within the age range of 3 months to 6 years); and sometimes findings: Generalized non-motor (absence) seizure and Generalized tonic seizure.

Organ System	Phenotype Count	Example Features
Brain and nerves	4	Bilateral tonic-clonic seizure, Febrile seizure (within the age range of 3 months to 6 years), Generalized non-motor (absence) seizure

Prognosis

Phenotype severity distribution: 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for generalized epilepsy with febrile seizures plus, type 4.

5 publications have been identified in PubMed for generalized epilepsy with febrile seizures plus, type 4. Research spans Epidemiology / Natural History (100%).

Recent Publications

Dell'Isola GB (2026). [PMID: 41739881](https://pubmed.ncbi.nlm.nih.gov/41739881/). *Epilepsia Open*. [Epidemiology / Natural History]
Wang Y (2026). [PMID: 42037703](https://pubmed.ncbi.nlm.nih.gov/42037703/). *Front Neurol*. [Epidemiology / Natural History]
Tan Q (2025). [PMID: 40186408](https://pubmed.ncbi.nlm.nih.gov/40186408/). *Dev Med Child Neurol*. [Epidemiology / Natural History]
Chen S (2025). [PMID: 41366559](https://pubmed.ncbi.nlm.nih.gov/41366559/). *J Neurol*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:56 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:609800

GARD

Genetic and Rare Diseases Info Center

GARD:18662

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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generalized epilepsy with febrile seizures plus, type 4

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

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