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Back to Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia — NIH Grants & Funding

Active and recent NIH-funded research on Childhood Acute Lymphoblastic Leukemia. Data from NIH RePORTER, last 36 months.

MONDO:0000870

NIH-funded research on Childhood Acute Lymphoblastic Leukemia

active grants

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$52.9M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(20)

Basic ScienceR01Active

Identifying Relapse Predictors and Therapeutic Vulnerabilities in Ph+ and Ph-like Acute Lymphoblastic Leukemia

Loh, Mignon et al.·SEATTLE CHILDREN'S HOSPITAL·SEATTLE, WA

$3,480,276 (FY2025)

Childhood Acute Lymphoblastic Leukemia — NIH Grants & Funding

Basic Science(20)

Identifying Relapse Predictors and Therapeutic Vulnerabilities in Ph+ and Ph-like Acute Lymphoblastic Leukemia

Cytomegalovirus as an etiologic and clinico-pathogenic factor in childhood acute lymphoblastic leukemia

Variant to Function Mapping of B-ALL Risk Loci

A Molecular Approach to Dissecting MEK-Mediated Phosphorylation in Pediatric Leukemia

The Role and Function of a Novel Signature Gene in BCR::ABL1 (Ph) B-cell Acute Lymphoblastic Leukemia

Investigating and targeting NSD2 mutation-driven leukemia transformation

Elucidate the Role of RNA Editing in Acute T-cell Lymphoblastic Leukemia Initiating Cells

Tracking Therapy-Resistant Alterations in Childhood Acute Lymphoblastic Leukemia

Mechanism(s) of TAL1- and NOTCH1-mediated Leukemogenesis

Mechanistic Study of PEG-asparaginase-Induced Liver Injury

Translational(5)

Targeted Inhibition in Leukemia

Discovery of MAP2K7 Inhibitors Through DNA-Encoded Chemical Screens to Treat T-Cell Acute Lymphoblastic Leukemia

Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Development of a Mouse Model to Study Targeted Therapy to Prevent CNS Invasion by Pediatric T-ALL

The design, synthesis, and characterization of potent and selective MEK7 inhibitors as targeted therapies for T-cell acute lymphoblastic leukemia

Clinical(8)

Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia

Harnessing the thymus for long-term tumor control with hematopoietic stem cell-derived naive CAR T cells

NCI Pediatric In Vivo Testing Program - Leukemia

A Healthy Weight Intervention for Family Stress during the Early Phases of ALL Treatment: NOURISH-ALL

Pediatric acute lymphoblastic leukemia: Improving outcomes through incorporation of novel targeted therapies into treatment for relapsed and newly diagnosed disease

Pharmacogenomic factors associated with severe acute toxicities and survival in pediatric Latino patients with acute lymphoblastic leukemia

Hypertension Intervention to Reduce Osteonecrosis in Children with Acute Lymphoblastic Leukemia

A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep

Epi / Nat. History(10)

Prevalence and persistence of the ETV6/RUNX1 pre-leukemic clone

Understanding the Increased Risk of Childhood Acute Lymphoblastic Leukemia in Latinos

Targeting obesity to improve survival from childhood acute lymphoblastic leukemia

Understanding the Increased Risk of Childhood Acute Lymphoblastic Leukemia in Latinos

Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium

Improving Outcome Disparities for Latino Children and Adolescents with Acute Lymphoblastic Leukemia

Identifying children with subclinical neurocognitive decline and susceptibility to oxidative damage during the early months of therapy for ALL

Effects of germline GATA3 variants on ALL somatic genomics and prognosis in multi-ethnic populations

Admixture analysis of acute lymphoblastic leukemia in African American children: the ADMIRAL Study

Sex and racial/ethnic differences in B-ALL genomics

Gene/Cell Therapy(6)

Clinical Development of Novel Therapies for Acute Lymphoblastic Leukemia

Clonal Therapy for Pediatric T-cell Acute Lymphoblastic Leukemia

Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-cell Acute Lymphoblastic Leukemia

Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)

Leveraging small molecule inhibitors to improve CD19 CAR T cell immunotherapy for KMT2A-rearranged ALL

Investigating the Role of Cdc73 in T-cell Acute Lymphoblastic Leukemia (T-ALL)

Biomarker / Dx(2)

Characterizing noncoding GWAS variants in acute lymphoblastic leukemia treatment outcome

Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia