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A germinoma arising from the central nervous system during childhood.
Biomarker and diagnostic research for childhood central nervous system germinoma has been reported in the published literature.
5 clinical trials registered, 3 recruiting. Interventions under study include procedural interventions, other interventions, and drug therapy. Pipeline includes 1 PHASE3, 1 PHASE2. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05564026](https://clinicaltrials.gov/study/NCT05564026) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:58 PM UTC
Molecular Epidemiology of Pediatric Germ Cell Tumors |
— |
Children's Oncology Group |
RECRUITING |
[NCT06368817](https://clinicaltrials.gov/study/NCT06368817) | A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma | PHASE2 | Children's Oncology Group | RECRUITING |
[NCT02375204](https://clinicaltrials.gov/study/NCT02375204) | Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors | PHASE3 | Alliance for Clinical Trials in Oncology | UNKNOWN |
[NCT04648462](https://clinicaltrials.gov/study/NCT04648462) | Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology | — | Maastricht Radiation Oncology | RECRUITING |
[NCT07589361](https://clinicaltrials.gov/study/NCT07589361) | Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors | — | Ruijin Hospital | NOT_YET_RECRUITING |
31 publications have been identified in PubMed for childhood central nervous system germinoma. Research spans Review / Meta-Analysis (28%), Epidemiology / Natural History (24%), and Case Report / Case Series (21%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 8 | 28% |
Disease patterns and progression | 7 | 24% |
Patient case studies | 6 | 21% |
Testing and diagnosis research | 3 | 10% |
Clinical study results | 3 | 10% |
Other research | 1 | 3% |
Laboratory research | 1 | 3% |
Abu-Arja MH (2026). [PMID: 41996009](https://pubmed.ncbi.nlm.nih.gov/41996009/). *J Neurooncol*. [Clinical Trial Publication]
Vitulli F (2026). [PMID: 41832330](https://pubmed.ncbi.nlm.nih.gov/41832330/). *Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery*. [Review / Meta-Analysis]
Antoniades E (2025). [PMID: 40361492](https://pubmed.ncbi.nlm.nih.gov/40361492/). *Cancers*. [Clinical Trial Publication]
Oh J (2025). [PMID: 40136384](https://pubmed.ncbi.nlm.nih.gov/40136384/). *Current oncology (Toronto, Ont.)*. [Epidemiology / Natural History]
De Martino L (2025). [PMID: 40277777](https://pubmed.ncbi.nlm.nih.gov/40277777/). *Current oncology (Toronto, Ont.)*. [Epidemiology / Natural History]
Yeo KK (2025). [PMID: 39959669](https://pubmed.ncbi.nlm.nih.gov/39959669/). *Frontiers in oncology*. [Diagnostic / Biomarker]
Song K (2025). [PMID: 40762663](https://pubmed.ncbi.nlm.nih.gov/40762663/). *Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery*. [Epidemiology / Natural History]
Hosaka S (2025). [PMID: 40839232](https://pubmed.ncbi.nlm.nih.gov/40839232/). *International journal of clinical oncology*. [Review / Meta-Analysis]
Hassanes S (2025). [PMID: 41523526](https://pubmed.ncbi.nlm.nih.gov/41523526/). *Cureus*. [Case Report / Case Series]
Liu T (2025). [PMID: 38100769](https://pubmed.ncbi.nlm.nih.gov/38100769/). *Retinal cases & brief reports*. [Case Report / Case Series]