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An ependymoma that arises from the central nervous system and occurs during childhood.
Biomarker and diagnostic research for childhood ependymoma has been reported in the published literature.
6 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and medical devices. Pipeline includes 2 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07061626](https://clinicaltrials.gov/study/NCT07061626) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 6:50 AM UTC
Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma |
PHASE1 |
Plus Therapeutics |
UNKNOWN |
[NCT05857969](https://clinicaltrials.gov/study/NCT05857969) | Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling | PHASE1 | Florida International University | RECRUITING |
[NCT05151718](https://clinicaltrials.gov/study/NCT05151718) | Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents | — | Institut Claudius Regaud | RECRUITING |
[NCT02359565](https://clinicaltrials.gov/study/NCT02359565) | Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma | PHASE1 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT02265770](https://clinicaltrials.gov/study/NCT02265770) | An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma | PHASE2 | Centre Leon Berard | RECRUITING |
143 publications have been identified in PubMed for childhood ependymoma. Research spans Review / Meta-Analysis (31%), Basic Science / Preclinical (24%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 37 | 31% |
Laboratory research | 28 | 24% |
Disease patterns and progression | 17 | 14% |
Clinical study results | 12 | 10% |
Testing and diagnosis research | 11 | 9% |
Patient case studies | 8 | 7% |
New treatment approaches | 4 | 3% |
Other research | 1 | 1% |
Thomas AG (2026). [PMID: 41274771](https://pubmed.ncbi.nlm.nih.gov/41274771/). *Neuroimaging Clin N Am*. [Review / Meta-Analysis]
Natarajan SK (2026). [PMID: 41639460](https://pubmed.ncbi.nlm.nih.gov/41639460/). *Nature*. [Basic Science / Preclinical]
Strauss JD (2026). [PMID: 41869074](https://pubmed.ncbi.nlm.nih.gov/41869074/). *Neurooncol Adv*. [Clinical Trial Publication]
Karsonovich T (2026). [PMID: 30571036](https://pubmed.ncbi.nlm.nih.gov/30571036/). *Unknown Journal*. [Diagnostic / Biomarker]
Cooper E (2026). [PMID: 41634415](https://pubmed.ncbi.nlm.nih.gov/41634415/). *Nat Genet*. [Basic Science / Preclinical]
Martell E (2026). [PMID: 41825848](https://pubmed.ncbi.nlm.nih.gov/41825848/). *Cancer Lett*. [Review / Meta-Analysis]
Jeong D (2026). [PMID: 41813893](https://pubmed.ncbi.nlm.nih.gov/41813893/). *Nature*. [Basic Science / Preclinical]
von Hoff K (2026). [PMID: 41026848](https://pubmed.ncbi.nlm.nih.gov/41026848/). *Neuro Oncol*. [Diagnostic / Biomarker]
Lago C (2026). [PMID: 41912763](https://pubmed.ncbi.nlm.nih.gov/41912763/). *Nat Protoc*. [Review / Meta-Analysis]
Chan M (2026). [PMID: 41665993](https://pubmed.ncbi.nlm.nih.gov/41665993/). *Proc Natl Acad Sci U S A*. [Clinical Trial Publication]