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cholestasis, progressive familial intrahepatic, 4 (PFIC4) - Clinical Profile, Genes & Research | Kisho | Kisho

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for cholestasis, progressive familial intrahepatic, 4.

39 publications have been identified in PubMed for cholestasis, progressive familial intrahepatic, 4. Research spans Case Report / Case Series (36%), Basic Science / Preclinical (36%), and Clinical Trial Publication (8%).

Research Type	Count	% of Total
Patient case studies	14	36%
Laboratory research	14	36%
Clinical study results	3	8%
Disease patterns and progression	3	8%
Testing and diagnosis research	2	5%
New treatment approaches	2	5%
Research summaries	1	3%

Recent Publications

Ramakrishna SH (2026). [PMID: 42238902](https://pubmed.ncbi.nlm.nih.gov/42238902/). *J Clin Exp Hepatol*. [Case Report / Case Series]
Latypov M (2026). [PMID: 41724238](https://pubmed.ncbi.nlm.nih.gov/41724238/). *Clinics and research in hepatology and gastroenterology*. [Basic Science / Preclinical]
Elkoofy NM (2026). [PMID: 40537152](https://pubmed.ncbi.nlm.nih.gov/40537152/). *Clinical genetics*. [Epidemiology / Natural History]
Cai B (2026). [PMID: 41598351](https://pubmed.ncbi.nlm.nih.gov/41598351/). *Journal of clinical medicine*. [Case Report / Case Series]
Latypov M (2026). [PMID: 41780879](https://pubmed.ncbi.nlm.nih.gov/41780879/). *Clinics and research in hepatology and gastroenterology*. [Case Report / Case Series]
Sakka R (2026). [PMID: 42224341](https://pubmed.ncbi.nlm.nih.gov/42224341/). *PLoS One*. [Review / Meta-Analysis]
Dong M (2026). [PMID: 42091197](https://pubmed.ncbi.nlm.nih.gov/42091197/). *Zhonghua Yi Xue Yi Chuan Xue Za Zhi*. [Case Report / Case Series]
Hasmee N (2026). [PMID: 42119236](https://pubmed.ncbi.nlm.nih.gov/42119236/). *J Pediatr Nurs*. [Case Report / Case Series]
Huimin Z (2025). [PMID: 41822262](https://pubmed.ncbi.nlm.nih.gov/41822262/). *Frontiers in gastroenterology (Lausanne, Switzerland)*. [Case Report / Case Series]
Yi S (2025). [PMID: 40454003](https://pubmed.ncbi.nlm.nih.gov/40454003/). *Gastro hep advances*. [Gene Therapy / Novel Therapeutics]

Organ System	Phenotype Count	Example Features
Digestive system	4	Hepatic failure, Liver scarring (cirrhosis) (cirrhosis), Intrahepatic cholestasis
Heart and blood vessels	1	Portal hypertension

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cholestasis, progressive familial intrahepatic, 4

Overview

Clinical Presentation

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Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

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External Resources

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cholestasis, progressive familial intrahepatic, 4

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team