A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone m...
Comprehensive, easy-to-understand information about this condition
How we create this content →Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
The documentation for chronic myelomonocytic leukemia is limited due to its relatively rare occurrence and the complexity of its clinical features. Systematic clinical studies are constrained by the low number of cases, which makes it challenging to gather comprehensive data. Additionally, the genetic basis of CMML is still being explored, contributing to the gaps in understanding its full clinical picture. This situation is not uncommon in rare diseases, where ongoing research is essential to uncover more about the condition.
To navigate your journey with chronic myelomonocytic leukemia, consider consulting with a hematologist or an oncologist who specializes in blood cancers. They can provide targeted insights into your condition and potential treatment options. Additionally, participating in clinical trials may offer access to cutting-edge therapies. You can find a list of active trials on ClinicalTrials.gov. Although there are currently no identified patient organizations specifically for CMML, resources like the National Organization for Rare Disorders (NORD) at rarediseases.org can provide support and information.
There are currently three orphan drugs designated for chronic myelomonocytic leukemia, including a co-packaged combination of azacitidine and cedazuridine, a recombinant human SIRPalpha Fc-fusion protein, and a humanized IgG1 monoclonal antibody targeting the leukocyte immunoglobulin-like receptor subfamily B4. Additionally, there are 127 active clinical trials investigating various aspects of CMML. For more information on these trials, you can visit ClinicalTrials.gov and search for chronic myelomonocytic leukemia.
Actionable guidance for navigating care for chronic myelomonocytic leukemia
To navigate your journey with chronic myelomonocytic leukemia, consider consulting with a hematologist or an oncologist who specializes in blood cancers. They can provide targeted insights into your condition and potential treatment options. Additionally, participating in clinical trials may offer access to cutting-edge therapies. You can find a list of active trials on ClinicalTrials.gov. Although there are currently no identified patient organizations specifically for CMML, resources like the National Organization for Rare Disorders (NORD) at rarediseases.org can provide support and information.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 4 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.