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A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
Biomarker and diagnostic research for clear cell sarcoma has been reported in the published literature.
13 clinical trials registered, 6 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 5 PHASE2, 5 PHASE1, 2 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07153887](https://clinicaltrials.gov/study/NCT07153887) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:54 PM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
Common questions about clear cell sarcoma
Vebreltinib for Advanced or Metastatic CCS |
PHASE2 |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
RECRUITING |
[NCT06942442](https://clinicaltrials.gov/study/NCT06942442) | A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma | PHASE2 | Sarcoma Alliance for Research through Collaboration | RECRUITING |
[NCT03967834](https://clinicaltrials.gov/study/NCT03967834) | Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group | NA | Institut Claudius Regaud | RECRUITING |
[NCT06625190](https://clinicaltrials.gov/study/NCT06625190) | Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors | PHASE1 | University of Florida | RECRUITING |
[NCT04897321](https://clinicaltrials.gov/study/NCT04897321) | B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) | PHASE1 | St. Jude Children's Research Hospital | RECRUITING |
173 publications have been identified in PubMed for clear cell sarcoma. Research spans Case Report / Case Series (32%), Review / Meta-Analysis (23%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 56 | 32% |
Research summaries | 39 | 23% |
Laboratory research | 22 | 13% |
Testing and diagnosis research | 18 | 10% |
Other research | 14 | 8% |
Disease patterns and progression | 12 | 7% |
Clinical study results | 10 | 6% |
New treatment approaches | 2 | 1% |
Xing ZW (2026). [PMID: 41644425](https://pubmed.ncbi.nlm.nih.gov/41644425/). *Zhonghua Bing Li Xue Za Zhi*. [Case Report / Case Series]
Tinoco G (2026). [PMID: 41749894](https://pubmed.ncbi.nlm.nih.gov/41749894/). *Cancers (Basel)*. [Basic Science / Preclinical]
Batson B (2026). [PMID: 42015602](https://pubmed.ncbi.nlm.nih.gov/42015602/). *Genes Chromosomes Cancer*. [Case Report / Case Series]
Zhao M (2026). [PMID: 42023520](https://pubmed.ncbi.nlm.nih.gov/42023520/). *Histopathology*. [Basic Science / Preclinical]
Braat J (2026). [PMID: 41700579](https://pubmed.ncbi.nlm.nih.gov/41700579/). *Am J Dermatopathol*. [Case Report / Case Series]
Yang BF (2026). [PMID: 41644426](https://pubmed.ncbi.nlm.nih.gov/41644426/). *Zhonghua Bing Li Xue Za Zhi*. [Epidemiology / Natural History]
Arciuolo D (2026). [PMID: 41706043](https://pubmed.ncbi.nlm.nih.gov/41706043/). *J Pathol*. [Basic Science / Preclinical]
Wu J (2026). [PMID: 41941244](https://pubmed.ncbi.nlm.nih.gov/41941244/). *Clin Nucl Med*. [Case Report / Case Series]
Lall N (2026). [PMID: 41638054](https://pubmed.ncbi.nlm.nih.gov/41638054/). *Clin Oncol (R Coll Radiol)*. [Clinical Trial Publication]
Walker EA (2026). [PMID: 41706083](https://pubmed.ncbi.nlm.nih.gov/41706083/). *Skeletal Radiol*. [Review / Meta-Analysis]
AI-curated news mentioning clear cell sarcoma
Updated Aug 29, 2026
A recent case series published in PubMed highlights the clinical characteristics and treatment outcomes of clear cell sarcoma in military personnel. This study contributes to the understanding of this rare cancer type and its implications for affected individuals.
A recent case report highlights clear cell Paget disease associated with underlying malignancy, contributing to the understanding of this rare condition. The review of literature provides insights into its clinical presentation and management.
A case report highlights the genomic and transcriptomic analysis of clear cell chondrosarcoma with somatic VHL inactivation. This study provides insights into the molecular underpinnings of this rare tumor type.