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A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma.
Biomarker and diagnostic research for myxofibrosarcoma has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
10 clinical trials registered, 5 recruiting. Interventions under study include procedural interventions, drug therapy, other interventions, and biologic therapy. Pipeline includes 5 PHASE2, 4 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05711615](https://clinicaltrials.gov/study/NCT05711615) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:58 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma |
PHASE1 |
National Cancer Institute (NCI) |
RECRUITING |
[NCT06239272](https://clinicaltrials.gov/study/NCT06239272) | NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) | PHASE1 | St. Jude Children's Research Hospital | RECRUITING |
[NCT07173972](https://clinicaltrials.gov/study/NCT07173972) | Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. | PHASE2 | Oslo University Hospital | RECRUITING |
[NCT07169344](https://clinicaltrials.gov/study/NCT07169344) | Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma | PHASE2 | Oslo University Hospital | RECRUITING |
[NCT04332874](https://clinicaltrials.gov/study/NCT04332874) | A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
131 publications have been identified in PubMed for myxofibrosarcoma. Research spans Case Report / Case Series (36%), Diagnostic / Biomarker (16%), and Basic Science / Preclinical (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 47 | 36% |
Testing and diagnosis research | 21 | 16% |
Laboratory research | 18 | 14% |
Research summaries | 14 | 11% |
Disease patterns and progression | 13 | 10% |
Clinical study results | 12 | 9% |
Other research | 4 | 3% |
New treatment approaches | 2 | 2% |
Nederkoorn MJL (2026). [PMID: 41868591](https://pubmed.ncbi.nlm.nih.gov/41868591/). *Immunooncol Technol*. [Basic Science / Preclinical]
Fetisov TI (2026). [PMID: 41718124](https://pubmed.ncbi.nlm.nih.gov/41718124/). *Med Sci (Basel)*. [Basic Science / Preclinical]
Gigineishvili D (2026). [PMID: 41960153](https://pubmed.ncbi.nlm.nih.gov/41960153/). *Case reports in oncology*. [Case Report / Case Series]
Wu S (2026). [PMID: 41521991](https://pubmed.ncbi.nlm.nih.gov/41521991/). *Quant Imaging Med Surg*. [Other]
Kito M (2026). [PMID: 41906255](https://pubmed.ncbi.nlm.nih.gov/41906255/). *Cancer Med*. [Basic Science / Preclinical]
Joachim K (2026). [PMID: 41899177](https://pubmed.ncbi.nlm.nih.gov/41899177/). *J Clin Med*. [Epidemiology / Natural History]
Borges N (2026). [PMID: 42174248](https://pubmed.ncbi.nlm.nih.gov/42174248/). *Ann Surg Oncol*. [Clinical Trial Publication]
Motta-Amar A (2026). [PMID: 41645242](https://pubmed.ncbi.nlm.nih.gov/41645242/). *J Cardiothorac Surg*. [Case Report / Case Series]
Gannon MC (2026). [PMID: 42147549](https://pubmed.ncbi.nlm.nih.gov/42147549/). *Cureus*. [Case Report / Case Series]
Kleijn TG (2026). [PMID: 41610211](https://pubmed.ncbi.nlm.nih.gov/41610211/). *Int J Surg Pathol*. [Diagnostic / Biomarker]