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A precancerous condition characterized by cellular proliferation of hematopoietic cells where a substantial proportion of the cells are derived from a single hematopoietic stem cell lineage.
Biomarker and diagnostic research for clonal hematopoiesis has been reported in the published literature.
17 clinical trials registered, 12 recruiting. Interventions under study include other interventions, drug therapy, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 1 PHASE2, 4 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05711173](https://clinicaltrials.gov/study/NCT05711173) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 4:41 PM UTC
Common questions about clonal hematopoiesis
Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE) |
NA |
University Hospital, Bordeaux |
RECRUITING |
[NCT06701214](https://clinicaltrials.gov/study/NCT06701214) | The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository | — | Vanderbilt-Ingram Cancer Center | RECRUITING |
[NCT05246813](https://clinicaltrials.gov/study/NCT05246813) | Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP) | — | Imelda Hospital, Bonheiden | RECRUITING |
[NCT06295965](https://clinicaltrials.gov/study/NCT06295965) | Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study | — | University of Washington | RECRUITING |
[NCT04711746](https://clinicaltrials.gov/study/NCT04711746) | Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism? | NA | Centre Hospitalier Universitaire, Amiens | RECRUITING |
244 publications have been identified in PubMed for clonal hematopoiesis. Kisho has analyzed 89 by research type. Research spans Basic Science / Preclinical (30%), Epidemiology / Natural History (26%), and Review / Meta-Analysis (22%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 27 | 30% |
Disease patterns and progression | 23 | 26% |
Research summaries | 20 | 22% |
Other research | 9 | 10% |
Patient case studies | 4 | 4% |
Clinical study results | 3 | 3% |
Testing and diagnosis research | 2 | 2% |
New treatment approaches | 1 | 1% |
Herbrich S (2026). [PMID: 41106379](https://pubmed.ncbi.nlm.nih.gov/41106379/). *Cancer Cell*. [Gene Therapy / Novel Therapeutics]
Tanguay M (2026). [PMID: 41791906](https://pubmed.ncbi.nlm.nih.gov/41791906/). *Cancer Treat Rev*. [Review / Meta-Analysis]
Agarwal G (2026). [PMID: 41477881](https://pubmed.ncbi.nlm.nih.gov/41477881/). *Science*. [Basic Science / Preclinical]
Liu W (2026). [PMID: 41449055](https://pubmed.ncbi.nlm.nih.gov/41449055/). *Chin Med J (Engl)*. [Epidemiology / Natural History]
Al-Sawaf O (2026). [PMID: 41528026](https://pubmed.ncbi.nlm.nih.gov/41528026/). *Blood*. [Epidemiology / Natural History]
Flynn S (2026). [PMID: 41206888](https://pubmed.ncbi.nlm.nih.gov/41206888/). *JAMA Cardiol*. [Epidemiology / Natural History]
Spetzler D (2025). [PMID: 40632963](https://pubmed.ncbi.nlm.nih.gov/40632963/). *N Engl J Med*. [Other]
Villaume MT (2025). [PMID: 39445405](https://pubmed.ncbi.nlm.nih.gov/39445405/). *Haematologica*. [Review / Meta-Analysis]
Cai X (2025). [PMID: 40681796](https://pubmed.ncbi.nlm.nih.gov/40681796/). *Nat Cancer*. [Review / Meta-Analysis]
Libby P (2025). [PMID: 39535811](https://pubmed.ncbi.nlm.nih.gov/39535811/). *JAMA Cardiol*. [Epidemiology / Natural History]