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A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.
Biomarker and diagnostic research for lymphoblastic lymphoma has been reported in the published literature.
1 FDA-approved treatment is available for lymphoblastic lymphoma, including NELARABINE (ARRANON, approved 2005). An additional 1 compound holds orphan drug designation.
Brand Name | Generic Name | Mechanism | Approved | Market Status |
|---|---|---|---|---|
115 clinical trials registered, 49 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 1 PHASE4, 9 PHASE3, 32 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06364423](https://clinicaltrials.gov/study/NCT06364423) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 3:00 PM UTC
Genetic and Rare Diseases Info Center
ARRANON
NELARABINE |
— |
2005 |
Available |
The following drugs have received orphan drug designation from the FDA for lymphoblastic lymphoma. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor | Designated | Exclusivity End | Designation Status |
|---|---|---|---|---|---|
autologous chimeric antigen receptor (CAR) T cells targeting CD7 | autologous chimeric antigen receptor (CAR) T cells targeting CD7 | Hebei Senlang Biotechnology Co. Ltd. | 2023 | — | Designated |
Gene therapy approaches for lymphoblastic lymphoma have been reported in the published literature.
115 trials found
Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias |
PHASE1 |
National Cancer Institute (NCI) |
RECRUITING |
[NCT06803745](https://clinicaltrials.gov/study/NCT06803745) | Standard-of-Care Reduced-Intensity Conditioning (RIC) With 200 Versus 400 cGy of Total Body Irradiation (TBI) in Patients With Acute Leukemia Undergoing First Allogeneic Blood or Marrow Transplantation (BMT) | NA | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | RECRUITING |
[NCT03959085](https://clinicaltrials.gov/study/NCT03959085) | Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy | PHASE3 | Children's Oncology Group | RECRUITING |
[NCT02393157](https://clinicaltrials.gov/study/NCT02393157) | Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL | PHASE2 | New York Medical College | RECRUITING |
[NCT06131801](https://clinicaltrials.gov/study/NCT06131801) | Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution | — | Children's Hospital Medical Center, Cincinnati | RECRUITING |
297 publications have been identified in PubMed for lymphoblastic lymphoma. Kisho has analyzed 165 by research type. Research spans Case Report / Case Series (30%), Review / Meta-Analysis (20%), and Clinical Trial Publication (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 50 | 30% |
Research summaries | 33 | 20% |
Clinical study results | 20 | 12% |
Disease patterns and progression | 19 | 12% |
Laboratory research | 18 | 11% |
Testing and diagnosis research | 11 | 7% |
Other research | 10 | 6% |
New treatment approaches | 4 | 2% |
Liu Z (2026). [PMID: 41618586](https://pubmed.ncbi.nlm.nih.gov/41618586/). *Pediatr Blood Cancer*. [Diagnostic / Biomarker]
Zhang H (2026). [PMID: 40736563](https://pubmed.ncbi.nlm.nih.gov/40736563/). *Eur J Nucl Med Mol Imaging*. [Diagnostic / Biomarker]
Cui W (2026). [PMID: 41021397](https://pubmed.ncbi.nlm.nih.gov/41021397/). *Acta Cytol*. [Basic Science / Preclinical]
Bosch-Schips J (2026). [PMID: 41611915](https://pubmed.ncbi.nlm.nih.gov/41611915/). *Pathologie (Heidelb)*. [Review / Meta-Analysis]
Di Giacomo D (2026). [PMID: 41791840](https://pubmed.ncbi.nlm.nih.gov/41791840/). *Blood*. [Basic Science / Preclinical]
Leijnen F (2026). [PMID: 41752218](https://pubmed.ncbi.nlm.nih.gov/41752218/). *Int J Mol Sci*. [Review / Meta-Analysis]
Bian W (2026). [PMID: 41824879](https://pubmed.ncbi.nlm.nih.gov/41824879/). *Medicine (Baltimore)*. [Review / Meta-Analysis]
Matijasic Stjepovic N (2026). [PMID: 41835666](https://pubmed.ncbi.nlm.nih.gov/41835666/). *Cureus*. [Epidemiology / Natural History]
Guo W (2026). [PMID: 41299066](https://pubmed.ncbi.nlm.nih.gov/41299066/). *Oncogene*. [Clinical Trial Publication]
Selim C (2026). [PMID: 42232536](https://pubmed.ncbi.nlm.nih.gov/42232536/). *Front Oncol*. [Epidemiology / Natural History]
AI-curated news mentioning lymphoblastic lymphoma
Updated Mar 8, 2026
A case study highlights advanced lymphoblastic lymphoma in the leukaemic phase, which resulted in sudden and fatal CNS hemorrhage. This underscores the critical need for awareness and research into the aggressive nature of this lymphoma variant.