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Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
9 clinical trials registered, 4 recruiting. Interventions under study include other interventions, procedural interventions, drug therapy, and medical devices. Pipeline includes 1 PHASE2, 3 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05663502](https://clinicaltrials.gov/study/NCT05663502) | Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers | — | AIDS Malignancy Consortium | RECRUITING |
[NCT01199562](https://clinicaltrials.gov/study/NCT01199562) | Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant | — | City of Hope Medical Center | ACTIVE_NOT_RECRUITING |
[NCT01137643](https://clinicaltrials.gov/study/NCT01137643) | Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
[NCT01815749](https://clinicaltrials.gov/study/NCT01815749) | Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma | PHASE1 | City of Hope Medical Center | ACTIVE_NOT_RECRUITING |
[NCT00544115](https://clinicaltrials.gov/study/NCT00544115) | Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders | PHASE2 | City of Hope Medical Center | ACTIVE_NOT_RECRUITING |
5 publications have been identified in PubMed for large-cell immunoblastic lymphoma. Research spans Review / Meta-Analysis (60%) and Case Report / Case Series (40%).
Rangoonwala HI (2026). [PMID: 32965972](https://pubmed.ncbi.nlm.nih.gov/32965972/). *Unknown Journal*. [Review / Meta-Analysis]
Chen BJ (2026). [PMID: 42108217](https://pubmed.ncbi.nlm.nih.gov/42108217/). *J Cutan Pathol*. [Case Report / Case Series]
Zanelli M (2025). [PMID: 40869163](https://pubmed.ncbi.nlm.nih.gov/40869163/). *Int J Mol Sci*. [Review / Meta-Analysis]
Będkowska D (2025). [PMID: 40002191](https://pubmed.ncbi.nlm.nih.gov/40002191/). *Cancers (Basel)*. [Review / Meta-Analysis]
S SS (2024). [PMID: 39651017](https://pubmed.ncbi.nlm.nih.gov/39651017/). *Cureus*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 11:26 AM UTC
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