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Congenital partial agenesis of pericardium is a rare, mostly asymptomatic, congenital heart malformation mainly characterized by the partial absence of the left pericardium. It is occasionally associated with chest pain or dyspnea and is usually incidentally diagnosed during surgery or at autopsy. Herniation and strangulation of a portion of the heart through the pericardial foramen may occur, resulting in myocardial acute ischemia and possible sudden death. Right side pericardium involvement is rare.
No clinical trials have been registered for congenital partial agenesis of pericardium.
12 publications have been identified in PubMed for congenital partial agenesis of pericardium. Research spans Case Report / Case Series (83%), Review / Meta-Analysis (8%), and Clinical Trial Publication (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 10 | 83% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:45 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
1 |
8% |
Clinical study results | 1 | 8% |
Sharma R (2026). [PMID: 40338327](https://pubmed.ncbi.nlm.nih.gov/40338327/). *Clinical research in cardiology : official journal of the German Cardiac Society*. [Case Report / Case Series]
Yakovlev S (2026). [PMID: 41725857](https://pubmed.ncbi.nlm.nih.gov/41725857/). *Methodist DeBakey cardiovascular journal*. [Case Report / Case Series]
Lyu Q (2026). [PMID: 41271255](https://pubmed.ncbi.nlm.nih.gov/41271255/). *J Clin Ultrasound*. [Case Report / Case Series]
Inoguchi K (2025). [PMID: 41173610](https://pubmed.ncbi.nlm.nih.gov/41173610/). *JACC. Case reports*. [Case Report / Case Series]
Sugimoto K (2025). [PMID: 40840406](https://pubmed.ncbi.nlm.nih.gov/40840406/). *Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology*. [Case Report / Case Series]
Gupta M (2025). [PMID: 40400823](https://pubmed.ncbi.nlm.nih.gov/40400823/). *Cureus*. [Case Report / Case Series]
Jafari F (2025). [PMID: 39955569](https://pubmed.ncbi.nlm.nih.gov/39955569/). *Journal of cardiothoracic surgery*. [Review / Meta-Analysis]
Lugata J (2025). [PMID: 41056657](https://pubmed.ncbi.nlm.nih.gov/41056657/). *International journal of surgery case reports*. [Case Report / Case Series]
Mu C (2025). [PMID: 39394030](https://pubmed.ncbi.nlm.nih.gov/39394030/). *Heart, lung & circulation*. [Clinical Trial Publication]
Patel AK (2025). [PMID: 40773027](https://pubmed.ncbi.nlm.nih.gov/40773027/). *The international journal of cardiovascular imaging*. [Case Report / Case Series]
AI-curated news mentioning congenital partial agenesis of pericardium
Updated Jun 5, 2026
A recent literature review and case series on congenital pericardial agenesis explores its clinical significance, suggesting it may not always be an innocent finding. The study highlights the need for further investigation into the implications of this condition.
A recent study discusses the challenges of percutaneous interventions in patients with congenital pericardial agenesis. The findings highlight the unique anatomical considerations and potential complications associated with this rare condition.