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congenital pulmonary venous return anomaly - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital pulmonary venous return anomaly

MONDO:0017705

Also known as:congenital pulmonary venous connection anomalyAPVRTAPVR

Overview

Congenital pulmonary venous return anomaly is a cardiac malformation where some or all of the pulmonary veins drain into the right atrium or the systemic veins, with or without the presence of pulmonary venous obstruction, leading to various manifestations such as fatigue, exertional dyspnea, pulmonary arterial hypertension, cyanosis and progressive congestive heart failure. The two main subtypes are congenital partial pulmonary venous return anomaly (PAPVC), where one or a few of the pulmonary veins are anomalous, and congenital total pulmonary venous return anomaly (TAPVC), where all of the pulmonary veins are anomalous.

Diagnosis

Biomarker and diagnostic research for congenital pulmonary venous return anomaly has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital pulmonary venous return anomaly.

231 publications have been identified in PubMed for congenital pulmonary venous return anomaly. Research spans Case Report / Case Series (58%), Review / Meta-Analysis (12%), and Epidemiology / Natural History (10%).

Research Type	Count	% of Total
Patient case studies	135	58%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:3090

GARD

Genetic and Rare Diseases Info Center

GARD:4599

Questions for Your Care Team

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congenital pulmonary venous return anomaly

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications