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Congenital temporomandibular joint ankylosis is a rare maxillofacial disorder characterized by significant reduction in mouth opening (i.e. from a few millimeters to a few centimeters) in the absence of acquired factors (e.g. trauma, infection) contributing to the ankylosis. It is associated with variable degrees of facial dysmorphism (i.e. lateral deviation of the mandible and chin, lower facial asymmetry, retrognathia, micrognathia, dental malocclusion) and patients typically present with feeding and breathing difficulties. Developmental delay, hypotonia, seizures, and additional dysmorphic features (e.g. pectus excavatum, low-set ears, hypoplastic alae nasi) have also been reported.
No clinical trials have been registered for congenital temporomandibular joint ankylosis.
6 publications have been identified in PubMed for congenital temporomandibular joint ankylosis. Research spans Case Report / Case Series (67%), Clinical Trial Publication (17%), and Gene Therapy / Novel Therapeutics (17%).
Marszałek-Kruk BA (2026). [PMID: 41753091](https://pubmed.ncbi.nlm.nih.gov/41753091/). *J Clin Med*. [Gene Therapy / Novel Therapeutics]
Preudhomme R (2025). [PMID: 39840734](https://pubmed.ncbi.nlm.nih.gov/39840734/). *Orthod Fr*. [Clinical Trial Publication]
Gerbino G (2025). [PMID: 40649015](https://pubmed.ncbi.nlm.nih.gov/40649015/). *J Clin Med*. [Case Report / Case Series]
Paul A (2024). [PMID: 38910731](https://pubmed.ncbi.nlm.nih.gov/38910731/). *Cureus*. [Case Report / Case Series]
Singh R (2024). [PMID: 39497910](https://pubmed.ncbi.nlm.nih.gov/39497910/). *J Oral Biol Craniofac Res*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:45 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning congenital temporomandibular joint ankylosis
Updated Feb 8, 2026
A rare case report highlights the association of temporomandibular joint ankylosis with psoriasis and familial Mediterranean fever. This finding may provide insights into the complex interplay between these conditions.