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Fibrous dysplasia is a genetic, non-inheritable skeletal disorder arising from osteoblastic differentiation defects that cause replacement of bone marrow and trabecular bone with fibrous stroma and immature bone. The condition may affect a single bone (monostotic), multiple bones (polyostotic), or essentially all bones (panostotic). Commonly affected skeletal sites include the skull, femur, tibia, and humerus. No specific gene is identified in this packet, consistent with the non-inheritable nature of the disorder.
Fibrous dysplasia is described as a genetic, non-inheritable disorder caused by osteoblastic differentiation defects. No specific gene is listed in this packet and no inheritance pattern is established. The condition does not run in families.
Specific diagnostic methods are not detailed in this packet. The condition is identified through its characteristic skeletal manifestations, including fibrous replacement of bone with associated structural and morphological changes.
No FDA-approved treatments are listed in this packet for fibrous dysplasia. Several clinical trials are currently active or in recruitment for this condition and related skeletal disorders.
6 trials found
Prognosis data is not available in this packet.
Several clinical trials are currently active or in development for fibrous dysplasia. Ongoing research includes epidemiological and multimodal data collection studies, biomechanical assessment of fracture risk in rare bone disorders including the fibrous dysplasia and McCune-Albright syndrome spectrum, and characterization of pain across this spectrum. Studies are primarily sponsored by academic medical centers and orthopedic institutions.
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:49 AM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning fibrous dysplasia
Updated Aug 3, 2026
A recent perspective highlights the significant unmet need for effective treatments in fibrous dysplasia and rare pediatric bone diseases. The article discusses current challenges and the necessity for innovative therapeutic approaches.
A new injectable matrix metalloproteinase-responsive nanoparticle hydrogel scaffold has been developed for sustained local drug delivery in fibrous dysplasia. This innovative approach could enhance treatment efficacy for patients with this rare bone disorder.
A preclinical study investigates the effects of anti-RANKL and Zoledronate therapies in a mouse model of fibrous dysplasia. The findings contribute to understanding potential treatment strategies for this rare bone disorder.