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Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities.
Biomarker and diagnostic research for rickets has been reported in the published literature.
18 clinical trials registered, 8 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 2 PHASE3, 1 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06481111](https://clinicaltrials.gov/study/NCT06481111) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:49 AM UTC
Genetic and Rare Diseases Info Center
Prospective Monocentric Registry of Patients Undergoing Vitamin D Treatment at San Raffaele Hospital
— |
IRCCS San Raffaele |
RECRUITING |
[NCT06065852](https://clinicaltrials.gov/study/NCT06065852) | National Registry of Rare Kidney Diseases | — | UK Kidney Association | RECRUITING |
[NCT06202027](https://clinicaltrials.gov/study/NCT06202027) | Post Marketing Surveillance Study to Observe Safety and Effectiveness of CRYSVITA® in S. Korean Patients | — | Kyowa Kirin Korea Co., Ltd. | RECRUITING |
[NCT07199829](https://clinicaltrials.gov/study/NCT07199829) | Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel | NA | Madigan Army Medical Center | RECRUITING |
[NCT07143552](https://clinicaltrials.gov/study/NCT07143552) | Bone Outcomes, Obesity, Sunlight, and Trauma in Children | — | Paracelsus Medical University | RECRUITING |
308 publications have been identified in PubMed for rickets. Kisho has analyzed 187 by research type. Research spans Review / Meta-Analysis (34%), Epidemiology / Natural History (17%), and Case Report / Case Series (16%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 63 | 34% |
Disease patterns and progression | 32 | 17% |
Patient case studies | 29 | 16% |
Laboratory research | 29 | 16% |
Clinical study results | 21 | 11% |
Testing and diagnosis research | 7 | 4% |
New treatment approaches | 5 | 3% |
Other research | 1 | 1% |
Yarovaya Y (2026). [PMID: 41987842](https://pubmed.ncbi.nlm.nih.gov/41987842/). *Open Respir Med J*. [Epidemiology / Natural History]
Kaur J (2026). [PMID: 30335299](https://pubmed.ncbi.nlm.nih.gov/30335299/). *Unknown Journal*. [Review / Meta-Analysis]
Buzato J (2026). [PMID: 42047649](https://pubmed.ncbi.nlm.nih.gov/42047649/). *J Am Dent Assoc*. [Case Report / Case Series]
Defabianis P (2026). [PMID: 41427455](https://pubmed.ncbi.nlm.nih.gov/41427455/). *Eur J Paediatr Dent*. [Review / Meta-Analysis]
Satheesh A (2026). [PMID: 41721181](https://pubmed.ncbi.nlm.nih.gov/41721181/). *Indian J Gastroenterol*. [Case Report / Case Series]
Nguyen TT (2026). [PMID: 41828612](https://pubmed.ncbi.nlm.nih.gov/41828612/). *Int J Mol Sci*. [Review / Meta-Analysis]
Dalamaga M (2026). [PMID: 41849024](https://pubmed.ncbi.nlm.nih.gov/41849024/). *Curr Nutr Rep*. [Review / Meta-Analysis]
Fujiwara K (2026). [PMID: 41047346](https://pubmed.ncbi.nlm.nih.gov/41047346/). *Endocr J*. [Epidemiology / Natural History]
Senda T (2026). [PMID: 41467305](https://pubmed.ncbi.nlm.nih.gov/41467305/). *FEBS J*. [Review / Meta-Analysis]
Del Toro Runzer C (2026). [PMID: 41521187](https://pubmed.ncbi.nlm.nih.gov/41521187/). *Bone Res*. [Review / Meta-Analysis]
AI-curated news mentioning rickets
Updated May 19, 2026
BioMarin's Phase 3 trial for its investigational therapy in ENPP1 deficiency failed to show clinical improvements, missing key secondary endpoints related to rickets severity and growth. This setback raises concerns about the future of their rare disease portfolio.