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secondary non-traumatic avascular necrosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

secondary non-traumatic avascular necrosis

MONDO:0018376

Also known as:secondary non-traumatic AVN

Overview

ResearchLimited published research (3 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Bone tissue death from poor blood supply (avascular necrosis); and common findings: Limitation of joint mobility, Bone pain, Autoimmunity, and Addictive alcohol use. 13 total HPO annotations.

Organ System	Phenotype Count	Example Features
Bones and joints	4	Bone tissue death from poor blood supply (avascular necrosis), Limitation of joint mobility, Bone pain

Prognosis

Phenotype severity distribution: 1 very common feature, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for secondary non-traumatic avascular necrosis.

3 publications have been identified in PubMed for secondary non-traumatic avascular necrosis. Research spans Clinical Trial Publication (67%) and Review / Meta-Analysis (33%).

Recent Publications

Su Y (2026). [PMID: 41145206](https://pubmed.ncbi.nlm.nih.gov/41145206/). *International journal of surgery (London, England)*. [Review / Meta-Analysis]
Gholami Z (2025). [PMID: 39931640](https://pubmed.ncbi.nlm.nih.gov/39931640/). *BMJ open sport & exercise medicine*. [Clinical Trial Publication]
Huang C (2025). [PMID: 41419875](https://pubmed.ncbi.nlm.nih.gov/41419875/). *BMC musculoskeletal disorders*. [Clinical Trial Publication]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 6:02 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:399180

GARD

Genetic and Rare Diseases Info Center

GARD:21661

Questions for Your Care Team

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secondary non-traumatic avascular necrosis

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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