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congenital trigeminal anesthesia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital trigeminal anesthesia

MONDO:0007384

Also known as:corneal hypesthesia, familialfamilial trigeminal anaesthesiafamilial trigeminal anesthesia

Overview

Congenital trigeminal anesthesia is a rare neuro-ophtalmological disorder characterized by a congenital sensory deficit involving all or some of the sensory components of the trigeminal nerve. Due to corneal anesthesia, it usually presents with recurrent, painless eye infections, painless corneal opacities and/or poorly healing, ulcerated wounds on the facial skin and mucosa (typically the buccal mucosa and/or nasal septum).

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital trigeminal anesthesia.

12 publications have been identified in PubMed for congenital trigeminal anesthesia. Research spans Case Report / Case Series (50%), Basic Science / Preclinical (25%), and Review / Meta-Analysis (17%).

Research Type	Count	% of Total
Patient case studies	6	50%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 10:42 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:122450

Orphanet

European rare disease database

Orphanet:231013

GARD

Genetic and Rare Diseases Info Center

GARD:10034

Questions for Your Care Team

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congenital trigeminal anesthesia

Overview

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

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Questions for Your Care Team

Questions for Your Care Team

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