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congenital velopharyngeal incompetence - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital velopharyngeal incompetence

MONDO:0008180

Also known as:palatopharyngeal incompetencevelopharyngeal incompetencevelopharyngeal insufficiency

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Overview

Failure of the soft palate to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (adenoidectomy; cleft palate) or an incompetent palatopharyngeal sphincter. It is characterized by hypernasal speech.

GeneticsMultifactorial

Clinical Trials5 registered · 3 recruiting

Clinical Presentation

Features include: Velopharyngeal insufficiency, Cleft palate, and Abnormality of the voice.

Organ System	Phenotype Count	Example Features
Head and neck	1	Cleft palate
Voice	1	Abnormality of the voice

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Diagnosis

Biomarker and diagnostic research for congenital velopharyngeal incompetence has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

5 clinical trials registered, 3 recruiting. Interventions under study include other interventions, medical devices, and procedural interventions. Pipeline includes 3 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07301021](https://clinicaltrials.gov/study/NCT07301021)

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 11:56 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:167500

Orphanet

European rare disease database

Orphanet:2291

GARD

Genetic and Rare Diseases Info Center

GARD:5470

Questions for Your Care Team

→Are any of the 5 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	34	32%
Clinical study results	28	27%
Disease patterns and progression	19	18%
Testing and diagnosis research	9	9%
Patient case studies	9	9%
Laboratory research	4	4%
Other research	1	1%
New treatment approaches	1	1%

congenital velopharyngeal incompetence

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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