Features include always present findings: Equinus calcaneus; and very common findings: Rocker bottom foot, Abnormality of the foot musculature, Achilles tendon contracture, and Pes valgus and others. 15 total HPO annotations.

HOXD10 encodes homeobox D10 (340 aa). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis Highest expression in Uterus (103.7 TPM) and Cervix Ectocervix (52.6 TPM).

Congenital vertical talus is associated with mutations in the HOXD10 gene on chromosome 2.

HOXD10 is classified as a druggable target (Transcription Factor category) with score 26.1.

Genetic testing for HOXD10 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for congenital vertical talus has been reported in the published literature.

Phenotype severity distribution: 1 always present feature, 5 very common features, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

No clinical trials have been registered for congenital vertical talus.

69 publications have been identified in PubMed for congenital vertical talus. Research spans Clinical Trial Publication (28%), Basic Science / Preclinical (26%), and Review / Meta-Analysis (17%).