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A disease involving the connective tissue.
Biomarker and diagnostic research for connective tissue disorder has been reported in the published literature.
29 clinical trials registered, 12 recruiting. Pipeline includes 3 PHASE4, 2 PHASE3, 2 PHASE2.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06716606](https://clinicaltrials.gov/study/NCT06716606) | A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE) |
Data assembled from 3 of 12 sources · Last updated Nov 3, 2026, 8:23 AM UTC
PHASE3 |
GlaxoSmithKline |
RECRUITING |
[NCT02234388](https://clinicaltrials.gov/study/NCT02234388) | Undifferentiated Connective Tissue Disease Registry | — | Hospital for Special Surgery, New York | RECRUITING |
[NCT04402086](https://clinicaltrials.gov/study/NCT04402086) | Rheumatology Patient Registry and Biorepository | — | Yale University | RECRUITING |
[NCT06104228](https://clinicaltrials.gov/study/NCT06104228) | 129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH) | PHASE2 | Bastiaan Driehuys | RECRUITING |
[NCT07180537](https://clinicaltrials.gov/study/NCT07180537) | Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders | NA | Terry L. Wahls | RECRUITING |
392 publications have been identified in PubMed for connective tissue disorder. Kisho has analyzed 129 by research type. Research spans Review / Meta-Analysis (28%), Basic Science / Preclinical (27%), and Epidemiology / Natural History (20%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 36 | 28% |
Laboratory research | 35 | 27% |
Disease patterns and progression | 26 | 20% |
Patient case studies | 22 | 17% |
Testing and diagnosis research | 5 | 4% |
Other research | 2 | 2% |
New treatment approaches | 2 | 2% |
Clinical study results | 1 | 1% |
Adigun R (2026). [PMID: 28613625](https://pubmed.ncbi.nlm.nih.gov/28613625/). *Unknown Journal*. [Review / Meta-Analysis]
Alcocer AD (2026). [PMID: 41915433](https://pubmed.ncbi.nlm.nih.gov/41915433/). *Physiology (Bethesda)*. [Review / Meta-Analysis]
Meyers AL (2026). [PMID: 32491606](https://pubmed.ncbi.nlm.nih.gov/32491606/). *Unknown Journal*. [Gene Therapy / Novel Therapeutics]
Alkurdi D (2026). [PMID: 41209845](https://pubmed.ncbi.nlm.nih.gov/41209845/). *JID Innov*. [Clinical Trial Publication]
Miolo G (2026). [PMID: 41338889](https://pubmed.ncbi.nlm.nih.gov/41338889/). *J Proteome Res*. [Basic Science / Preclinical]
Cohen SA (2026). [PMID: 41496654](https://pubmed.ncbi.nlm.nih.gov/41496654/). *Curr Opin Ophthalmol*. [Review / Meta-Analysis]
Sahu G (2026). [PMID: 42199566](https://pubmed.ncbi.nlm.nih.gov/42199566/). *Cureus*. [Epidemiology / Natural History]
Yang X (2026). [PMID: 41813411](https://pubmed.ncbi.nlm.nih.gov/41813411/). *Taiwan J Obstet Gynecol*. [Other]
Zheng A (2025). [PMID: 39800123](https://pubmed.ncbi.nlm.nih.gov/39800123/). *J Vasc Surg*. [Basic Science / Preclinical]
Choubey S (2025). [PMID: 40613922](https://pubmed.ncbi.nlm.nih.gov/40613922/). *Rheumatol Int*. [Review / Meta-Analysis]
AI-curated news mentioning connective tissue disorder
Updated Oct 3, 2026
Recent research identifies loss of function variants in the ADAMTS6 gene as a cause of a novel connective tissue disorder characterized by heart defects, aortic aneurysms, and neurodevelopmental features. This discovery could lead to new diagnostic and therapeutic strategies for affected patients.
A new study explores the complexities of pulmonary arterial hypertension (PAH) in patients with connective tissue diseases, highlighting the paradoxical signs of venous and capillary involvement. This research may inform future therapeutic strategies and improve patient outcomes.
A narrative review highlights the role of exhaled nitric oxide measurement in patients with connective tissue diseases linked to interstitial lung disease. This research could provide insights into non-invasive monitoring and management strategies for affected patients.