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Continuous spikes and waves during sleep (CSWS) is a rare epileptic encephalopathy of childhood characterized by seizures, an electroencephalographic (EEG) pattern of electrical status epilepticus in sleep (ESES) and neurocognitive regression in at least 2 domains of development.
Biomarker and diagnostic research for continuous spikes and waves during sleep has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for continuous spikes and waves during sleep.
50 publications have been identified in PubMed for continuous spikes and waves during sleep. Research spans Epidemiology / Natural History (24%), Clinical Trial Publication (22%), and Case Report / Case Series (20%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 12 | 24% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 6:51 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Clinical study results
11 |
22% |
Patient case studies | 10 | 20% |
Testing and diagnosis research | 5 | 10% |
Research summaries | 5 | 10% |
Laboratory research | 5 | 10% |
Other research | 1 | 2% |
New treatment approaches | 1 | 2% |
van Arnhem MML (2026). [PMID: 41133317](https://pubmed.ncbi.nlm.nih.gov/41133317/). *Epilepsia*. [Clinical Trial Publication]
Lessa VCC (2026). [PMID: 41818393](https://pubmed.ncbi.nlm.nih.gov/41818393/). *Stereotact Funct Neurosurg*. [Case Report / Case Series]
Soto-Insuga V (2026). [PMID: 42044942](https://pubmed.ncbi.nlm.nih.gov/42044942/). *Neurologia (Engl Ed)*. [Clinical Trial Publication]
Setia P (2026). [PMID: 40736317](https://pubmed.ncbi.nlm.nih.gov/40736317/). *J Child Neurol*. [Case Report / Case Series]
Specchio N (2026). [PMID: 42047579](https://pubmed.ncbi.nlm.nih.gov/42047579/). *Epilepsia*. [Review / Meta-Analysis]
Menderes D (2026). [PMID: 41616747](https://pubmed.ncbi.nlm.nih.gov/41616747/). *Epilepsy research*. [Review / Meta-Analysis]
İriş M (2026). [PMID: 41570778](https://pubmed.ncbi.nlm.nih.gov/41570778/). *Seizure*. [Clinical Trial Publication]
Singh S (2026). [PMID: 41270422](https://pubmed.ncbi.nlm.nih.gov/41270422/). *Seizure*. [Diagnostic / Biomarker]
Balaram N (2026). [PMID: 42247783](https://pubmed.ncbi.nlm.nih.gov/42247783/). *Epilepsy Behav*. [Epidemiology / Natural History]
Ng AC (2026). [PMID: 41558409](https://pubmed.ncbi.nlm.nih.gov/41558409/). *Epilepsy Behav*. [Clinical Trial Publication]