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corneal dystrophy, Meesmann, 2 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

corneal dystrophy, Meesmann, 2

MONDO:0032904

Also known as:meesmann corneal dystrophy 2MECD2

Overview

GeneticsAutosomal dominant · KRT3 (chr 12)

ResearchLimited published research (4 articles)

Clinical Presentation

Features include: Recurrent corneal erosions, Epiphora, and Photophobia.

Organ System	Phenotype Count	Example Features
Eyes	1	Recurrent corneal erosions

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

KRT3 encodes keratin 3 (628 aa). Highest expression in Esophagus Mucosa (5.0 TPM) and Vagina (0.8 TPM).

Corneal dystrophy, Meesmann, 2 is associated with mutations in the KRT3 gene on chromosome 12.

KRT3 is classified as a druggable target with score 0.0.

Diagnosis

Genetic testing for KRT3 is available. Testing is considered confirmatory for diagnosis.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for corneal dystrophy, Meesmann, 2.

4 publications have been identified in PubMed for corneal dystrophy, Meesmann, 2. Research spans Other (25%), Review / Meta-Analysis (25%), and Case Report / Case Series (25%).

Recent Publications

Charoenrook V (2026). [PMID: 41683752](https://pubmed.ncbi.nlm.nih.gov/41683752/). *Int J Mol Sci*. [Basic Science / Preclinical]
Liskova P (2025). [PMID: 40079222](https://pubmed.ncbi.nlm.nih.gov/40079222/). *Clin Exp Ophthalmol*. [Review / Meta-Analysis]
De Faria A (2025). [PMID: 39941522](https://pubmed.ncbi.nlm.nih.gov/39941522/). *J Clin Med*. [Case Report / Case Series]
Kulkarni R (2025). [PMID: 41364730](https://pubmed.ncbi.nlm.nih.gov/41364730/). *J Particip Med*. [Other]

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:618767

Questions for Your Care Team

→Should I pursue genetic testing for KRT3, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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corneal dystrophy, Meesmann, 2

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team