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A thymic epithelial neoplasm characterized by the presence of neoplastic large, polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. The neoplastic cells are arranged around perivascular spaces and along septa. Immature T-lymphocytes are also present. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate malignancy. The majority of cases occur in the anterior mediastinum as Masaoka stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less frequently.
No clinical trials have been registered for cortical thymoma.
8 publications have been identified in PubMed for cortical thymoma. Research spans Case Report / Case Series (50%), Basic Science / Preclinical (38%), and Review / Meta-Analysis (13%).
Adnyana IWL (2025). [PMID: 39897139](https://pubmed.ncbi.nlm.nih.gov/39897139/). *Acta Med Philipp*. [Case Report / Case Series]
Parmar K (2025). [PMID: 41503579](https://pubmed.ncbi.nlm.nih.gov/41503579/). *Mediastinum*. [Review / Meta-Analysis]
Gochi AM (2025). [PMID: 41210436](https://pubmed.ncbi.nlm.nih.gov/41210436/). *AME Case Rep*. [Case Report / Case Series]
Nisar A (2024). [PMID: 39532334](https://pubmed.ncbi.nlm.nih.gov/39532334/). *BMJ Case Rep*. [Case Report / Case Series]
Tomonari Y (2024). [PMID: 39359893](https://pubmed.ncbi.nlm.nih.gov/39359893/). *J Toxicol Pathol*. [Basic Science / Preclinical]
Balaji AN (2024). [PMID: 39385927](https://pubmed.ncbi.nlm.nih.gov/39385927/). *Cureus*. [Case Report / Case Series]
Data assembled from 2 of 12 sources · Last updated Sep 19, 2026, 6:42 AM UTC
Nagata H (2024). [PMID: 39166351](https://pubmed.ncbi.nlm.nih.gov/39166351/). *Cancer Sci*. [Basic Science / Preclinical]
Yasumizu Y (2024). [PMID: 39180749](https://pubmed.ncbi.nlm.nih.gov/39180749/). *Cell Rep*. [Basic Science / Preclinical]