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corticobasal syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

corticobasal syndrome

MONDO:0018696

Find Clinical TrialsTrials

Overview

Corticobasal syndrome (CBS) is a rare neurodegenerative disease characterized by multifaceted motor system dysfunctions and cognitive defects such as asymmetric rigidity, bradykinesia, limb apraxia, and visuospatial dysfunction.

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials13 registered · 6 recruiting

Diagnosis

Biomarker and diagnostic research for corticobasal syndrome has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for corticobasal syndrome. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for corticobasal syndrome, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for corticobasal syndrome. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

13 clinical trials registered, 6 recruiting. Interventions under study include other interventions, medical devices, and drug therapy. Pipeline includes 2 PHASE2, 3 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04715399](https://clinicaltrials.gov/study/NCT04715399)

Data assembled from 5 of 12 sources · Last updated Sep 17, 2026, 11:38 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:454887

GARD

Genetic and Rare Diseases Info Center

GARD:13168

Questions for Your Care Team

→Are any of the 13 active clinical trials a good fit for my situation?
→What is the current development status of Fasudil hydrochloride, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	36	22%
Testing and diagnosis research	34	21%
Disease patterns and progression	34	21%
Patient case studies	32	20%
Laboratory research	18	11%
Other research	4	2%
Clinical study results	2	1%
New treatment approaches	2	1%

Kisho

corticobasal syndrome

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.

corticobasal syndrome

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.