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CREST syndrome is a subtype of limited cutaneous systemic sclerosis (lcSSc) whose name is an acronym for the cardinal clinical features of the syndrome: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia.
Biomarker and diagnostic research for CREST syndrome has been reported in the published literature.
1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily industry-sponsored.
84 publications have been identified in PubMed for CREST syndrome. Research spans Epidemiology / Natural History (36%), Case Report / Case Series (24%), and Review / Meta-Analysis (15%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 30 | 36% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:53 AM UTC
European rare disease database
Common questions about CREST syndrome
Patient case studies |
20 |
24% |
Research summaries | 13 | 15% |
Testing and diagnosis research | 10 | 12% |
Clinical study results | 6 | 7% |
Laboratory research | 5 | 6% |
Kumari S (2026). [PMID: 41522843](https://pubmed.ncbi.nlm.nih.gov/41522843/). *Clin Case Rep*. [Case Report / Case Series]
Gadeholt O (2026). [PMID: 41627436](https://pubmed.ncbi.nlm.nih.gov/41627436/). *Z Rheumatol*. [Case Report / Case Series]
Souffez M (2026). [PMID: 41708172](https://pubmed.ncbi.nlm.nih.gov/41708172/). *BMJ Open*. [Review / Meta-Analysis]
Martínez-López J (2026). [PMID: 41236837](https://pubmed.ncbi.nlm.nih.gov/41236837/). *Arthritis Rheumatol*. [Clinical Trial Publication]
Derk CT (2026). [PMID: 42100061](https://pubmed.ncbi.nlm.nih.gov/42100061/). *Mediterr J Rheumatol*. [Review / Meta-Analysis]
Zayed HS (2026). [PMID: 42156501](https://pubmed.ncbi.nlm.nih.gov/42156501/). *Sci Rep*. [Epidemiology / Natural History]
Moschetti L (2026). [PMID: 41782907](https://pubmed.ncbi.nlm.nih.gov/41782907/). *Ther Adv Musculoskelet Dis*. [Epidemiology / Natural History]
Yılmaz E (2026). [PMID: 42234184](https://pubmed.ncbi.nlm.nih.gov/42234184/). *Rheumatol Int*. [Epidemiology / Natural History]
Filipánits K (2026). [PMID: 41594676](https://pubmed.ncbi.nlm.nih.gov/41594676/). *Biomolecules*. [Diagnostic / Biomarker]
Dai X (2026). [PMID: 42238603](https://pubmed.ncbi.nlm.nih.gov/42238603/). *Front Immunol*. [Basic Science / Preclinical]
AI-curated news mentioning CREST syndrome
Updated Jul 31, 2026
A case report details a ruptured right middle cerebral artery aneurysm associated with CREST syndrome, contributing to the understanding of this rare condition. The literature review highlights the complexities of managing such cases.
The CDC highlights the rising threat of carbapenem-resistant Enterobacteriaceae (CRE) in U.S. healthcare settings, emphasizing the urgent need for awareness and action among patients and healthcare providers. This drug-resistant bacteria poses significant risks, leading to life-threatening infections that are increasingly difficult to treat.