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limited cutaneous systemic sclerosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

limited cutaneous systemic sclerosis

MONDO:0016358

Also known as:limited cutaneous systemic sclerodermalimited sclerodermasystemic sclerosis, limited

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Overview

Limited cutaneous systemic sclerosis (lcSSc) is a subtype of systemic sclerosis (SSc) characterized by the association of Raynaud's phenomenon with skin fibrosis limited to the hands, face, feet and forearms.

Clinical Trials1 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abnormality of the skin, Skin color changes (abnormality of skin pigmentation), Hypopigmented skin patches, and Autoimmunity and others; and common findings: Difficulty swallowing (dysphagia), Nausea and vomiting, Gastroesophageal reflux, and Visible small blood vessels on mucous membranes (mucosal telangiectasiae) and others. 15 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	6

Diagnosis

Biomarker and diagnostic research for limited cutaneous systemic sclerosis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 5 very common features, 6 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily industry-sponsored.

56 publications have been identified in PubMed for limited cutaneous systemic sclerosis. Research spans Case Report / Case Series (43%), Epidemiology / Natural History (22%), and Review / Meta-Analysis (15%).

Research Type	Count	% of Total
Patient case studies	23	43%

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 12:04 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:220402

GARD

Genetic and Rare Diseases Info Center

GARD:1053

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

limited cutaneous systemic sclerosis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

limited cutaneous systemic sclerosis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications