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Limited systemic sclerosis (lSSc) (or SSc sine scleroderma) is a subset of systemic sclerosis (SSc) characterized by organ involvement in the absence of fibrosis of the skin.
Biomarker and diagnostic research for limited systemic sclerosis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily industry-sponsored.
164 publications have been identified in PubMed for limited systemic sclerosis. Research spans Review / Meta-Analysis (33%), Epidemiology / Natural History (19%), and Case Report / Case Series (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 45 | 33% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 12:59 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Disease patterns and progression |
26 |
19% |
Patient case studies | 18 | 13% |
Laboratory research | 16 | 12% |
Testing and diagnosis research | 15 | 11% |
Clinical study results | 11 | 8% |
Other research | 4 | 3% |
New treatment approaches | 3 | 2% |
Melideo HM (2026). [PMID: 42037288](https://pubmed.ncbi.nlm.nih.gov/42037288/). *G Ital Nefrol*. [Case Report / Case Series]
Kjærsgaard Andersen R (2026). [PMID: 41405899](https://pubmed.ncbi.nlm.nih.gov/41405899/). *JAMA Dermatol*. [Diagnostic / Biomarker]
Morales-Pertuz C (2026). [PMID: 41772467](https://pubmed.ncbi.nlm.nih.gov/41772467/). *BMC Infect Dis*. [Case Report / Case Series]
Huang J (2026). [PMID: 41451447](https://pubmed.ncbi.nlm.nih.gov/41451447/). *Arthritis Rheumatol*. [Basic Science / Preclinical]
Wang J (2026). [PMID: 41483081](https://pubmed.ncbi.nlm.nih.gov/41483081/). *Clin Rheumatol*. [Other]
Kleefeld F (2026). [PMID: 41934478](https://pubmed.ncbi.nlm.nih.gov/41934478/). *Acta Neuropathol*. [Basic Science / Preclinical]
Nigro A (2026). [PMID: 41712154](https://pubmed.ncbi.nlm.nih.gov/41712154/). *Intern Emerg Med*. [Case Report / Case Series]
Foeldvari I (2026). [PMID: 41638996](https://pubmed.ncbi.nlm.nih.gov/41638996/). *Best Pract Res Clin Rheumatol*. [Review / Meta-Analysis]
Radić M (2026). [PMID: 41682782](https://pubmed.ncbi.nlm.nih.gov/41682782/). *J Clin Med*. [Review / Meta-Analysis]
Quigley EMM (2026). [PMID: 41997504](https://pubmed.ncbi.nlm.nih.gov/41997504/). *Gastroenterology*. [Review / Meta-Analysis]
AI-curated news mentioning limited systemic sclerosis
Updated Sep 18, 2026
A real-life analysis from the EUSTAR database investigates the long-term outcomes of proton pump inhibitor use in patients with systemic sclerosis. The study provides insights into treatment efficacy and patient management strategies.
A recent EUSTAR cohort study evaluates the effectiveness of oral anticoagulants in treating precapillary pulmonary hypertension linked to systemic sclerosis. The findings contribute to understanding treatment options for this rare condition.
A recent study identifies a distinct gastrointestinal symptom profile associated with clinically relevant fatigue in systemic sclerosis. This research enhances understanding of symptomatology in patients, potentially guiding future therapeutic strategies.