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criss-cross heart - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

criss-cross heart

MONDO:0015449

Also known as:criss-cross atrioventricular relationshipssuperoinferior ventriclestwisted atrioventricular connections

Overview

Criss cross heart (CCH) is a cardiac malformation where the inflow streams of the two ventricles cross due to twisting of the heart about its major axis. The clinical features depend on the particular cardiac defects associated, like simple or corrected transposition of the great arteries and ventricular septal defects.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Cyanosis and Abnormal cardiovascular system morphology; and common findings: Ventricular septal defect, Abnormal mitral valve morphology, Pulmonic stenosis, and Transposition of the great arteries and others. 13 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	4	Ventricular septal defect, Abnormal mitral valve morphology, Mitral stenosis

Diagnosis

Biomarker and diagnostic research for criss-cross heart has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 very common features, 9 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for criss-cross heart.

13 publications have been identified in PubMed for criss-cross heart. Research spans Case Report / Case Series (54%), Review / Meta-Analysis (15%), and Diagnostic / Biomarker (8%).

Research Type	Count	% of Total
Patient case studies	7	54%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:01 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1461

GARD

Genetic and Rare Diseases Info Center

GARD:18724

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

criss-cross heart

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

criss-cross heart

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications