Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogen...
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation for Cushing syndrome is limited primarily due to its complex nature and the variability of symptoms among individuals. Additionally, because Cushing syndrome is relatively rare, systematic clinical studies have been sparse, leading to gaps in understanding its full clinical spectrum. The absence of identified genes further complicates the characterization of the condition, leaving many questions unanswered.
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Currently, there are several active clinical trials exploring various aspects of Cushing syndrome, with a total of 52 trials available. One notable orphan drug in development is metyrapone, which is being investigated for its potential to manage the condition. For more information on ongoing trials, you can visit ClinicalTrials.gov and search for Cushing syndrome: https://clinicaltrials.gov/search?cond=Cushing%20syndrome.
Actionable guidance for navigating care for Cushing syndrome
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the Cushing syndrome community
Helpful links for rare disease information and support
The documentation for Cushing syndrome is limited primarily due to its complex nature and the variability of symptoms among individuals. Additionally, because Cushing syndrome is relatively rare, systematic clinical studies have been sparse, leading to gaps in understanding its full clinical spectrum. The absence of identified genes further complicates the characterization of the condition, leaving many questions unanswered.
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Currently, there are several active clinical trials exploring various aspects of Cushing syndrome, with a total of 52 trials available. One notable orphan drug in development is metyrapone, which is being investigated for its potential to manage the condition. For more information on ongoing trials, you can visit ClinicalTrials.gov and search for Cushing syndrome: https://clinicaltrials.gov/search?cond=Cushing%20syndrome.
Actionable guidance for navigating care for Cushing syndrome
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the Cushing syndrome community
Helpful links for rare disease information and support
The documentation for Cushing syndrome is limited primarily due to its complex nature and the variability of symptoms among individuals. Additionally, because Cushing syndrome is relatively rare, systematic clinical studies have been sparse, leading to gaps in understanding its full clinical spectrum. The absence of identified genes further complicates the characterization of the condition, leaving many questions unanswered.
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Currently, there are several active clinical trials exploring various aspects of Cushing syndrome, with a total of 52 trials available. One notable orphan drug in development is metyrapone, which is being investigated for its potential to manage the condition. For more information on ongoing trials, you can visit ClinicalTrials.gov and search for Cushing syndrome: https://clinicaltrials.gov/search?cond=Cushing%20syndrome.
Actionable guidance for navigating care for Cushing syndrome
To navigate Cushing syndrome effectively, consider consulting an endocrinologist who specializes in adrenal disorders. They can provide insights into the management of the condition and potential treatment options. Additionally, the National Adrenal Diseases Foundation (NADF) offers resources and support for individuals affected by adrenal disorders. You can find more information at https://nadf.us. Participating in patient registries or natural history studies may also provide valuable insights into your condition and help advance research.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the Cushing syndrome community
Helpful links for rare disease information and support
Clinical profile data for this condition is not yet available. Phenotype information may still be loading below.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Feb 8, 2026
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
1 peer-reviewed source from PubMed
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 3 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.