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Cutaneous leukocytoclastic angiitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs. Systemic symptoms including fever, cough, hemoptysis, sinusitis, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, hematochezia, paresthesia, weakness, and hematuria may be observed. Skin biopsy reveals exudates rich in neutrophils, endothelial damage, fibrin deposition, and leukocytoclasis in postcapillary venules of small vessels. Cutaneous leukocytoclastic angiitis can be idiopathic (in up to 50% of cases) or secondary to infections, medications (such as antituberculosis medication), collagen vascular diseases, or neoplasms.
Biomarker and diagnostic research for cutaneous leukocytoclastic angiitis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for cutaneous leukocytoclastic angiitis.
57 publications have been identified in PubMed for cutaneous leukocytoclastic angiitis. Research spans Case Report / Case Series (74%), Review / Meta-Analysis (11%), and Epidemiology / Natural History (9%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 42 | 74% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 4:02 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
6 |
11% |
Disease patterns and progression | 5 | 9% |
Testing and diagnosis research | 3 | 5% |
Laboratory research | 1 | 2% |
de Carvalho JF (2026). [PMID: 41655516](https://pubmed.ncbi.nlm.nih.gov/41655516/). *Seminars in arthritis and rheumatism*. [Review / Meta-Analysis]
Sagris M (2026). [PMID: 42125530](https://pubmed.ncbi.nlm.nih.gov/42125530/). *Eur Heart J Case Rep*. [Case Report / Case Series]
Salihoglu A (2026). [PMID: 41208292](https://pubmed.ncbi.nlm.nih.gov/41208292/). *Current opinion in rheumatology*. [Diagnostic / Biomarker]
Li X (2026). [PMID: 42058431](https://pubmed.ncbi.nlm.nih.gov/42058431/). *Front Med (Lausanne)*. [Case Report / Case Series]
Carrasquel M (2026). [PMID: 41694997](https://pubmed.ncbi.nlm.nih.gov/41694997/). *Cureus*. [Epidemiology / Natural History]
Nakamura T (2026). [PMID: 41895206](https://pubmed.ncbi.nlm.nih.gov/41895206/). *An Bras Dermatol*. [Diagnostic / Biomarker]
Baigrie D (2026). [PMID: 29489227](https://pubmed.ncbi.nlm.nih.gov/29489227/). *Unknown Journal*. [Review / Meta-Analysis]
Manduca S (2026). [PMID: 41813060](https://pubmed.ncbi.nlm.nih.gov/41813060/). *Journal of cutaneous pathology*. [Case Report / Case Series]
Longi AA (2026). [PMID: 41777950](https://pubmed.ncbi.nlm.nih.gov/41777950/). *Cureus*. [Case Report / Case Series]
Pouy R (2026). [PMID: 41577611](https://pubmed.ncbi.nlm.nih.gov/41577611/). *Vascular diseases (Paris, France)*. [Case Report / Case Series]
AI-curated news mentioning cutaneous leukocytoclastic angiitis
Updated May 10, 2026
A case report highlights cutaneous leukocytoclastic vasculitis as a rare adverse event associated with infliximab treatment in Crohn's disease. This finding underscores the need for vigilance in monitoring adverse effects in patients receiving this therapy.