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Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.
Estimated prevalence: Unknown (Unknown prevalence).
2 clinical trials registered, 2 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
20 publications have been identified in PubMed for hypocomplementemic urticarial vasculitis. Research spans Case Report / Case Series (65%), Review / Meta-Analysis (20%), and Basic Science / Preclinical (10%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 13 | 65% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 10:32 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries |
4 |
20% |
Laboratory research | 2 | 10% |
Disease patterns and progression | 1 | 5% |
Tao X (2026). [PMID: 42092754](https://pubmed.ncbi.nlm.nih.gov/42092754/). *Cell Mol Biol Lett*. [Basic Science / Preclinical]
Bianchi C (2026). [PMID: 41807955](https://pubmed.ncbi.nlm.nih.gov/41807955/). *Pediatric rheumatology online journal*. [Case Report / Case Series]
Hu W (2026). [PMID: 41877830](https://pubmed.ncbi.nlm.nih.gov/41877830/). *Journal of inflammation research*. [Epidemiology / Natural History]
Bouziani E (2025). [PMID: 41316694](https://pubmed.ncbi.nlm.nih.gov/41316694/). *The American journal of case reports*. [Case Report / Case Series]
Ergun T (2025). [PMID: 39600289](https://pubmed.ncbi.nlm.nih.gov/39600289/). *Current opinion in rheumatology*. [Review / Meta-Analysis]
Abdwani R (2025). [PMID: 39666950](https://pubmed.ncbi.nlm.nih.gov/39666950/). *Rheumatology (Oxford, England)*. [Case Report / Case Series]
Taş Ö (2025). [PMID: 40455313](https://pubmed.ncbi.nlm.nih.gov/40455313/). *Clinical rheumatology*. [Review / Meta-Analysis]
Mut Quej JE (2025). [PMID: 41037713](https://pubmed.ncbi.nlm.nih.gov/41037713/). *Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)*. [Review / Meta-Analysis]
Aparicio EE (2025). [PMID: 41589185](https://pubmed.ncbi.nlm.nih.gov/41589185/). *Cureus*. [Case Report / Case Series]
Dorian L (2025). [PMID: 40937243](https://pubmed.ncbi.nlm.nih.gov/40937243/). *Cureus*. [Case Report / Case Series]
AI-curated news mentioning hypocomplementemic urticarial vasculitis
Updated Jun 10, 2026
A recent study highlights hypocomplementemic urticarial vasculitis as a rare presentation that can reveal underlying systemic lupus erythematosus and Sjögren's disease. This discovery emphasizes the need for awareness of these associations in clinical practice.