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Cysticercosis is a parasitic infectious disease characterized by cyst formation in the target tissue of Taenia solium (tapeworm) parasite larvae ingested via the feces of a human with a tapeworm (human-to-human fecal-oral transmission) leading to variable clinical manifestations in muscle, the brain, spinal cord, and eyes. Infection of muscle tissue is generally asymptomatic. Cyst development in the brain and spinal cord is known as neurocysticercosis (NCC) and may cause seizures and headache. NCC can follow a serious course and may be life-threatening. Severe cases of cysticercosis are treated with albendazole and anti-inflammatory drugs.
Features include very common findings: Nervous system problems (abnormality of the nervous system); and common findings: Seizure, Cerebral calcification, Increased CSF protein concentration, and Somatic sensory dysfunction and others. 49 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 18 | Nervous system problems (abnormality of the nervous system), Seizure, Cerebral calcification |
Biomarker and diagnostic research for cysticercosis has been reported in the published literature.
No approved treatments are currently available for cysticercosis. An additional 2 compounds hold orphan drug designation.
While no drugs are FDA-approved specifically for cysticercosis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for cysticercosis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
Phenotype severity distribution: 1 very common feature, 14 common features.
Estimated prevalence: Unknown (Unknown prevalence).
4 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE4, 1 PHASE2, 1 NA. Research is primarily sponsored by academic and government institutions.
268 publications have been identified in PubMed for cysticercosis. Kisho has analyzed 53 by research type. Research spans Review / Meta-Analysis (32%), Epidemiology / Natural History (26%), and Case Report / Case Series (21%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 17 |
Data assembled from 6 of 12 sources · Last updated Sep 18, 2026, 3:06 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Lab test results | 3 | Increased CSF protein concentration, Elevated antibody levels (increased circulating immunoglobulin concentration), Increased anti-parasite IgE antibody level |
Heart and blood vessels | 3 | Abnormal subarachnoid space morphology, Abnormal heart muscle (abnormal myocardium morphology), Stroke |
Eyes | 3 | Diplopia, Retinal detachment, Abnormal optic chiasm morphology |
Bones and joints | 2 | Abnormal skeletal muscle morphology, Abnormality of the vertebral column |
Muscles | 2 | Abnormal skeletal muscle morphology, Calcification of muscles |
Designated
Exclusivity End |
|---|
Designation Status |
|---|
oxfendazole | oxfendazole | Oxfendazole Development Group | 2017 | — | Designated |
Praziquantel | Praziquantel | EM Pharmaceuticals, Inc. | 1988 | — | Withdrawn |
oxfendazole is referenced in active clinical trials for cysticercosis (designated 2017).
Praziquantel is referenced in active clinical trials for cysticercosis (designated 1988).
4 trials found
32%
Disease patterns and progression | 14 | 26% |
Patient case studies | 11 | 21% |
Laboratory research | 6 | 11% |
Testing and diagnosis research | 4 | 8% |
Other research | 1 | 2% |
Hall WA (2026). [PMID: 32809402](https://pubmed.ncbi.nlm.nih.gov/32809402/). *Unknown Journal*. [Diagnostic / Biomarker]
Pizzitutti F (2026). [PMID: 41997225](https://pubmed.ncbi.nlm.nih.gov/41997225/). *Int J Parasitol*. [Epidemiology / Natural History]
Akamboe J (2026). [PMID: 41666435](https://pubmed.ncbi.nlm.nih.gov/41666435/). *Am J Trop Med Hyg*. [Epidemiology / Natural History]
Sadaow L (2026). [PMID: 41575056](https://pubmed.ncbi.nlm.nih.gov/41575056/). *Parasite*. [Basic Science / Preclinical]
Franco-Muñoz C (2025). [PMID: 40872264](https://pubmed.ncbi.nlm.nih.gov/40872264/). *Pathogens*. [Epidemiology / Natural History]
Hossain MS (2025). [PMID: 40735286](https://pubmed.ncbi.nlm.nih.gov/40735286/). *Front Vet Sci*. [Review / Meta-Analysis]
Sharma A (2025). [PMID: 40348080](https://pubmed.ncbi.nlm.nih.gov/40348080/). *Parasitol Int*. [Epidemiology / Natural History]
Odeniran PO (2025). [PMID: 40789451](https://pubmed.ncbi.nlm.nih.gov/40789451/). *Acta Trop*. [Review / Meta-Analysis]
Kapoor A (2025). [PMID: 40208172](https://pubmed.ncbi.nlm.nih.gov/40208172/). *Ophthalmology*. [Basic Science / Preclinical]
Singh RK (2025). [PMID: 40376341](https://pubmed.ncbi.nlm.nih.gov/40376341/). *Cureus*. [Case Report / Case Series]