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A systemic infection caused by the Gram-positive bacterium Tropheryma whipplei. It affects the small intestine resulting in malabsorption. Other sites or systems affected by the infection are the joints, central nervous system, and the cardiovascular system.
Biomarker and diagnostic research for Whipple disease has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for Whipple disease.
175 publications have been identified in PubMed for Whipple disease. Kisho has analyzed 132 by research type. Research spans Case Report / Case Series (39%), Review / Meta-Analysis (37%), and Epidemiology / Natural History (9%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 52 | 39% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Whipple disease
Research summaries
49 |
37% |
Disease patterns and progression | 12 | 9% |
Laboratory research | 9 | 7% |
Testing and diagnosis research | 5 | 4% |
Other research | 2 | 2% |
Clinical study results | 2 | 2% |
New treatment approaches | 1 | 1% |
Lázár E (2026). [PMID: 41028908](https://pubmed.ncbi.nlm.nih.gov/41028908/). *Nat Rev Genet*. [Review / Meta-Analysis]
Zhang L (2026). [PMID: 41975532](https://pubmed.ncbi.nlm.nih.gov/41975532/). *Infect Dis Poverty*. [Review / Meta-Analysis]
Shah S (2026). [PMID: 41503173](https://pubmed.ncbi.nlm.nih.gov/41503173/). *ACG Case Rep J*. [Case Report / Case Series]
Pan Y (2026). [PMID: 41924426](https://pubmed.ncbi.nlm.nih.gov/41924426/). *Front Cell Infect Microbiol*. [Clinical Trial Publication]
Huang Y (2026). [PMID: 41544799](https://pubmed.ncbi.nlm.nih.gov/41544799/). *Metabolism*. [Epidemiology / Natural History]
Agüera-Sánchez A (2026). [PMID: 41631710](https://pubmed.ncbi.nlm.nih.gov/41631710/). *J Cutan Pathol*. [Case Report / Case Series]
Amado C (2026). [PMID: 40975490](https://pubmed.ncbi.nlm.nih.gov/40975490/). *Ann Allergy Asthma Immunol*. [Review / Meta-Analysis]
Sposato A (2026). [PMID: 41591248](https://pubmed.ncbi.nlm.nih.gov/41591248/). *Radiology*. [Case Report / Case Series]
Salvi M (2026). [PMID: 41240044](https://pubmed.ncbi.nlm.nih.gov/41240044/). *JACC Case Rep*. [Case Report / Case Series]
Weichert H (2026). [PMID: 40858158](https://pubmed.ncbi.nlm.nih.gov/40858158/). *Fortschr Neurol Psychiatr*. [Review / Meta-Analysis]