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solitary rectal ulcer syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

solitary rectal ulcer syndrome

MONDO:0016208

Overview

Solitary rectal ulcer syndrome (SRUS) is a rare rectal disease characterized by rectal bleeding, abdominal pain, passage of mucus, sensation of incomplete evacuation, straining at defecation and rectal prolapsed, secondary to ischemic changes in the rectum.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Hematochezia; and common findings: Abdominal pain, Intermittent diarrhea, Chronic constipation, and Anal pain. 16 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	7	Abdominal pain, Intermittent diarrhea, Chronic constipation

Diagnosis

Biomarker and diagnostic research for solitary rectal ulcer syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 very common feature, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for solitary rectal ulcer syndrome.

23 publications have been identified in PubMed for solitary rectal ulcer syndrome. Research spans Case Report / Case Series (48%), Clinical Trial Publication (17%), and Review / Meta-Analysis (13%).

Research Type	Count	% of Total
Patient case studies	11	48%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 2:47 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:209964

GARD

Genetic and Rare Diseases Info Center

GARD:20444

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

solitary rectal ulcer syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

solitary rectal ulcer syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications