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Natural killer (NK)-cell enteropathy is a benign NK-cell lymphoproliferative disease characterized by minor abdominal symptoms (abdominal pain, diverticulosis, constipation and reflux) due to NK cell-derived lesions in the mucosal layer of the gastrointestinal tract and often mistaken for NK or T-cell lymphoma.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for NK-cell enteropathy.
7 publications have been identified in PubMed for NK-cell enteropathy. Research spans Review / Meta-Analysis (57%), Case Report / Case Series (29%), and Basic Science / Preclinical (14%).
Jiang Y (2026). [PMID: 42130625](https://pubmed.ncbi.nlm.nih.gov/42130625/). *Front Oncol*. [Case Report / Case Series]
Jeong PS (2026). [PMID: 40280544](https://pubmed.ncbi.nlm.nih.gov/40280544/). *J Adv Res*. [Basic Science / Preclinical]
Jiang B (2026). [PMID: 40491213](https://pubmed.ncbi.nlm.nih.gov/40491213/). *Int J Surg Pathol*. [Review / Meta-Analysis]
Lohneis P (2025). [PMID: 41410944](https://pubmed.ncbi.nlm.nih.gov/41410944/). *Pathologie (Heidelb)*. [Review / Meta-Analysis]
Jiang S (2025). [PMID: 40503479](https://pubmed.ncbi.nlm.nih.gov/40503479/). *World J Radiol*. [Case Report / Case Series]
Loghavi S (2025). [PMID: 39862928](https://pubmed.ncbi.nlm.nih.gov/39862928/). *Hum Pathol*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 2:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about NK-cell enteropathy
Li X (2024). [PMID: 38642003](https://pubmed.ncbi.nlm.nih.gov/38642003/). *J Cutan Pathol*. [Review / Meta-Analysis]