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A very rare condition characterized by generalized proliferation of pulmonary neuroendocrine cells. It manifests as progressive cough and dyspnea. It is considered a precursor for pulmonary carcinoid tumor.
Biomarker and diagnostic research for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
31 publications have been identified in PubMed for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Research spans Case Report / Case Series (55%), Review / Meta-Analysis (29%), and Basic Science / Preclinical (6%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 17 | 55% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:20 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries |
9 |
29% |
Laboratory research | 2 | 6% |
Other research | 1 | 3% |
Testing and diagnosis research | 1 | 3% |
Disease patterns and progression | 1 | 3% |
Davis AJ (2026). [PMID: 42264414](https://pubmed.ncbi.nlm.nih.gov/42264414/). *Semin Ultrasound CT MR*. [Review / Meta-Analysis]
Llewellyn DC (2026). [PMID: 42221035](https://pubmed.ncbi.nlm.nih.gov/42221035/). *Endocr Oncol*. [Review / Meta-Analysis]
Al-Sergani AH (2026). [PMID: 42261548](https://pubmed.ncbi.nlm.nih.gov/42261548/). *Cureus*. [Review / Meta-Analysis]
O'Callaghan M (2026). [PMID: 41561106](https://pubmed.ncbi.nlm.nih.gov/41561106/). *ERJ open research*. [Case Report / Case Series]
Gorospe L (2026). [PMID: 41936792](https://pubmed.ncbi.nlm.nih.gov/41936792/). *Med Clin (Barc)*. [Case Report / Case Series]
Koumarianou A (2026). [PMID: 41526992](https://pubmed.ncbi.nlm.nih.gov/41526992/). *Endocrine reviews*. [Review / Meta-Analysis]
Majumdar U (2026). [PMID: 41783948](https://pubmed.ncbi.nlm.nih.gov/41783948/). *Current opinion in pulmonary medicine*. [Review / Meta-Analysis]
Gawdi R (2026). [PMID: 41956149](https://pubmed.ncbi.nlm.nih.gov/41956149/). *J Thorac Cardiovasc Surg*. [Other]
Peixoto MSBC (2025). [PMID: 39813497](https://pubmed.ncbi.nlm.nih.gov/39813497/). *Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia*. [Case Report / Case Series]
Ledford DK (2025). [PMID: 39542142](https://pubmed.ncbi.nlm.nih.gov/39542142/). *The Journal of allergy and clinical immunology*. [Review / Meta-Analysis]