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A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor.
Biomarker and diagnostic research for germ cell tumor has been reported in the published literature.
73 clinical trials registered, 30 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 5 PHASE3, 25 PHASE2, 14 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05455918](https://clinicaltrials.gov/study/NCT05455918) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
Paclitaxel/Ifosfamide/Cisplatin Chemotherapy for High Risk Pediatric Germ Cell Tumor |
PHASE2 |
Yonsei University |
RECRUITING |
[NCT05874063](https://clinicaltrials.gov/study/NCT05874063) | Thromboprophylaxis in Good and Intermediate Prognosis Advanced Germ Cell Tumors | PHASE3 | Gustave Roussy, Cancer Campus, Grand Paris | RECRUITING |
[NCT05672043](https://clinicaltrials.gov/study/NCT05672043) | Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China | — | Beijing Tiantan Hospital | RECRUITING |
[NCT04804007](https://clinicaltrials.gov/study/NCT04804007) | Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT | PHASE2 | Nabil Adra | RECRUITING |
[NCT06421805](https://clinicaltrials.gov/study/NCT06421805) | Establishing Prospective Mediastinal Tumor Database of PUMCH | — | Peking Union Medical College Hospital | RECRUITING |
284 publications have been identified in PubMed for germ cell tumor. Kisho has analyzed 218 by research type. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (24%), and Epidemiology / Natural History (17%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 67 | 31% |
Research summaries | 53 | 24% |
Disease patterns and progression | 36 | 17% |
Laboratory research | 19 | 9% |
Other research | 15 | 7% |
Testing and diagnosis research | 13 | 6% |
Clinical study results | 13 | 6% |
New treatment approaches | 2 | 1% |
Chen L (2026). [PMID: 42133855](https://pubmed.ncbi.nlm.nih.gov/42133855/). *Int Braz J Urol*. [Case Report / Case Series]
Kumar L (2026). [PMID: 41808696](https://pubmed.ncbi.nlm.nih.gov/41808696/). *Cureus*. [Case Report / Case Series]
Zeng J (2026). [PMID: 41689870](https://pubmed.ncbi.nlm.nih.gov/41689870/). *Urol Oncol*. [Clinical Trial Publication]
Zhang Y (2026). [PMID: 41634291](https://pubmed.ncbi.nlm.nih.gov/41634291/). *Sci Rep*. [Basic Science / Preclinical]
Agarwal A (2026). [PMID: 41553468](https://pubmed.ncbi.nlm.nih.gov/41553468/). *Pediatr Radiol*. [Other]
Brecher A (2026). [PMID: 41480952](https://pubmed.ncbi.nlm.nih.gov/41480952/). *Fetal Pediatr Pathol*. [Case Report / Case Series]
Feldman DR (2026). [PMID: 42277552](https://pubmed.ncbi.nlm.nih.gov/42277552/). *Cancer Med*. [Epidemiology / Natural History]
Stucchi S (2026). [PMID: 41418783](https://pubmed.ncbi.nlm.nih.gov/41418783/). *Stem Cell Reports*. [Basic Science / Preclinical]
Bowling GC (2026). [PMID: 41687980](https://pubmed.ncbi.nlm.nih.gov/41687980/). *Gene*. [Review / Meta-Analysis]
Noto Y (2026). [PMID: 41736172](https://pubmed.ncbi.nlm.nih.gov/41736172/). *Pathol Int*. [Case Report / Case Series]
AI-curated news mentioning germ cell tumor
Updated Jul 10, 2026
A case study highlights the diagnostic challenges of primary high-grade intraperitoneal sarcoma in an 8-year-old girl, initially misidentified as a germ cell tumor. This report emphasizes the need for careful differential diagnosis in pediatric oncology.
A new study identifies risk factors and causes of early death in germ cell tumors, providing critical insights for improving patient outcomes. This research highlights the need for targeted interventions in this rare cancer population.
A new study provides the first description of an orthotopically located spontaneously ruptured non-seminomatous metastatic germ cell tumor. This research contributes to the understanding of rare tumor presentations and may inform future clinical approaches.
Tarik's story highlights the challenges faced by individuals with rare germ cell tumors and hypopituitarism, emphasizing the importance of visibility for rare diseases. His journey serves as a reminder of the resilience and support within the rare disease community.