Distal Biliary Tract Carcinoma — Clinical Trials

MONDO:00037074 active·1 recruitingLast updated: Mar 20, 2026, 4:10 PM

Trial Landscape

Distal Biliary Tract Carcinoma has an emerging clinical trial program, driven by drug treatment and procedure.

Recruiting

Active Trials

By Approach

Drug Treatment4

Procedure2

Biological Therapy1

1 additional trials involve behavioral, dietary, diagnostic, or observational approaches.

By Phase

Phase 1

Phase 2

Sponsor Types

NIH3Academic/Other1

Trial Locations

United States4 trials

Canada1 trial

Trials often recruit across multiple countries, so totals exceed the trial count.

4 Trials

Phase 1Recruiting

NCT05285358

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

Sponsor:City of Hope Medical Center

United StatesStarted: Sep 2022Est. completion: Oct 2028Updated: Mar 2026

Phase 2Active, Not Recruiting

NCT05564403

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Feb 2024Est. completion: May 2026Updated: Mar 2026

Phase 2Active, Not Recruiting

NCT04941287

Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Dec 2021Est. completion: Apr 2026Updated: May 2025

Phase 1Active, Not Recruiting

NCT04491942

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

Sponsor:National Cancer Institute (NCI)

United StatesStarted: Aug 2021Est. completion: Jun 2026Updated: Mar 2026

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 20, 2026 at 4:10 PM

Distal Biliary Tract Carcinoma — Clinical Trials

Trial Landscape

By Approach

By Phase

Sponsor Types

Trial Locations

4 Trials

Open Trials1

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

Active Trials3

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer