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Distal symphalangism is a very rare bone disorder characterized by ankylosis of the distal interphalangeal joints of the hands and/or feet.
Features include very common findings: Joint stiffness, Symphalangism affecting the phalanges of the hand, and Camptodactyly of finger; and sometimes findings: Synostosis of carpal bones. 11 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Arms and legs | 4 | Distal foot symphalangism, Distal symphalangism of hands, Symphalangism affecting the phalanges of the hand |
Biomarker and diagnostic research for distal symphalangism has been reported in the published literature.
Phenotype severity distribution: 3 very common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for distal symphalangism.
16 publications have been identified in PubMed for distal symphalangism. Research spans Case Report / Case Series (31%), Other (19%), and Review / Meta-Analysis (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 5 | 31% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 9:39 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Bones and joints |
3 |
Absent dorsal skin creases over affected joints, Synostosis of carpal bones, Joint stiffness |
Skin | 2 | Small nail, Absent dorsal skin creases over affected joints |
Head and neck | 1 | Craniosynostosis |
3 |
19% |
Research summaries | 2 | 13% |
Clinical study results | 2 | 13% |
Disease patterns and progression | 2 | 13% |
Testing and diagnosis research | 1 | 6% |
Laboratory research | 1 | 6% |
Köseoğlu GM (2026). [PMID: 42153583](https://pubmed.ncbi.nlm.nih.gov/42153583/). *Am J Med Genet A*. [Diagnostic / Biomarker]
Elsherbini A (2026). [PMID: 41689580](https://pubmed.ncbi.nlm.nih.gov/41689580/). *J Hand Surg Am*. [Review / Meta-Analysis]
Lőrincz A (2025). [PMID: 40364231](https://pubmed.ncbi.nlm.nih.gov/40364231/). *J Clin Med*. [Clinical Trial Publication]
Rips J (2025). [PMID: 40444971](https://pubmed.ncbi.nlm.nih.gov/40444971/). *Am J Med Genet A*. [Case Report / Case Series]
Erdogan EN (2025). [PMID: 40317680](https://pubmed.ncbi.nlm.nih.gov/40317680/). *Am J Med Genet A*. [Other]
Zhou R (2025). [PMID: 40222314](https://pubmed.ncbi.nlm.nih.gov/40222314/). *J Plast Reconstr Aesthet Surg*. [Epidemiology / Natural History]
Ünsel-Bolat G (2025). [PMID: 40415676](https://pubmed.ncbi.nlm.nih.gov/40415676/). *Dev Neurobiol*. [Case Report / Case Series]
Han Q (2025). [PMID: 40078620](https://pubmed.ncbi.nlm.nih.gov/40078620/). *Plast Reconstr Surg Glob Open*. [Clinical Trial Publication]
Perkins CH (2025). [PMID: 40017010](https://pubmed.ncbi.nlm.nih.gov/40017010/). *Foot Ankle Spec*. [Case Report / Case Series]
Zhu T (2025). [PMID: 40606564](https://pubmed.ncbi.nlm.nih.gov/40606564/). *Phenomics*. [Basic Science / Preclinical]