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early-onset autosomal dominant Alzheimer disease (EOFAD) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

early-onset autosomal dominant Alzheimer disease

MONDO:0015140

Also known as:EOFADearly-onset familial autosomal dominant Alzheimer diseaseearly-onset, autosomal dominant Alzheimer disease

Find Clinical TrialsTrials

Overview

A progressive dementia with reduction of cognitive functions. It presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.

OnsetINFANTILE, LATE, MIDDLE_AGE

Clinical Trials2 registered

Diagnosis

Biomarker and diagnostic research for early-onset autosomal dominant Alzheimer disease has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

21 publications have been identified in PubMed for early-onset autosomal dominant Alzheimer disease. Research spans Basic Science / Preclinical (48%), Case Report / Case Series (43%), and Diagnostic / Biomarker (5%).

Research Type	Count	% of Total
Laboratory research	10

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 10:32 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1020

GARD

Genetic and Rare Diseases Info Center

GARD:12798

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

early-onset autosomal dominant Alzheimer disease

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease.

Novel Frameshift Variant in SORL1 Gene Identified in a EOAD Family Causes APP Sorting Dysfunction and Endolysosomal Swelling.

early-onset autosomal dominant Alzheimer disease

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease.

Novel Frameshift Variant in SORL1 Gene Identified in a EOAD Family Causes APP Sorting Dysfunction and Endolysosomal Swelling.