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Ectodermal dysplasia-syndactyly syndrome is a rare, genetic ectodermal dysplasia syndrome characterized by sparse to absent scalp hair, eyebrows, and eyelashes (with pili torti when present), widely spaced, conical-shaped teeth with peg-shaped, conical crowns and enamel hypoplasia and palmoplantar hyperkeratosis, associated with partial cutaneous syndactyly in hands and feet.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for ectodermal dysplasia-syndactyly syndrome.
3 publications have been identified in PubMed for ectodermal dysplasia-syndactyly syndrome. Research spans Case Report / Case Series (67%) and Review / Meta-Analysis (33%).
Wang Y (2025). [PMID: 39577073](https://pubmed.ncbi.nlm.nih.gov/39577073/). *Breast*. [Review / Meta-Analysis]
Abu Assab D (2025). [PMID: 40586252](https://pubmed.ncbi.nlm.nih.gov/40586252/). *Isr Med Assoc J*. [Case Report / Case Series]
Jith G (2024). [PMID: 38726487](https://pubmed.ncbi.nlm.nih.gov/38726487/). *J Hand Surg Asian Pac Vol*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:42 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center