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A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include eosinophilia, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn wd, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Biomarker and diagnostic research for eosinophilia-myalgia syndrome has been reported in the published literature.
No clinical trials have been registered for eosinophilia-myalgia syndrome.
8 publications have been identified in PubMed for eosinophilia-myalgia syndrome. Research spans Case Report / Case Series (63%), Diagnostic / Biomarker (13%), and Review / Meta-Analysis (13%).
Pinal-Fernández I (2025). [PMID: 40543296](https://pubmed.ncbi.nlm.nih.gov/40543296/). *Med Clin (Barc)*. [Review / Meta-Analysis]
Hazzard I (2025). [PMID: 41480468](https://pubmed.ncbi.nlm.nih.gov/41480468/). *Cureus*. [Case Report / Case Series]
Lee A (2025). [PMID: 40341081](https://pubmed.ncbi.nlm.nih.gov/40341081/). *BMJ Case Rep*. [Case Report / Case Series]
Ihssan HH (2025). [PMID: 39881778](https://pubmed.ncbi.nlm.nih.gov/39881778/). *Radiol Case Rep*. [Case Report / Case Series]
Naidu S (2025). [PMID: 39991423](https://pubmed.ncbi.nlm.nih.gov/39991423/). *Cureus*. [Case Report / Case Series]
Stone CJ (2024). [PMID: 39135762](https://pubmed.ncbi.nlm.nih.gov/39135762/). *JAAD Case Rep*. [Case Report / Case Series]
Data assembled from 2 of 12 sources · Last updated Oct 4, 2026, 6:18 AM UTC
Genetic and Rare Diseases Info Center
Park JE (2024). [PMID: 38594832](https://pubmed.ncbi.nlm.nih.gov/38594832/). *J Appl Toxicol*. [Basic Science / Preclinical]
Niehues T (2024). [PMID: 39381601](https://pubmed.ncbi.nlm.nih.gov/39381601/). *Allergol Select*. [Diagnostic / Biomarker]
AI-curated news mentioning eosinophilia-myalgia syndrome
Updated Sep 1, 2026
A new publication discusses eosinophilia and hypereosinophilia, providing a practical approach to navigating their broad differential diagnosis. This resource may aid clinicians in identifying underlying causes and managing these conditions effectively.
A rare case study highlights auricular angiolymphoid hyperplasia with eosinophilia linked to chronic hearing aid use. This finding contributes to the understanding of potential complications associated with long-term hearing aid usage.