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episodic angioedema with eosinophilia (EAE) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

episodic angioedema with eosinophilia

MONDO:0500000

Also known as:EAEGleich syndromeGleich's syndrome

Overview

A disorder characterized by episodes of swelling under the skin (angioedema) and an elevated number of the white blood cells known as eosinophils (eosinophilia). During these episodes, symptoms of hives (urticaria), fever, swelling, weight gain and eosinophilia may occur. Symptoms usually appear every 3-4 weeks and resolve on their own within several days. Other cells may be elevated during the episodes, such as neutrophils and lymphocytes. Although the syndrome is often considered a subtype of the idiopathic hypereosinophilic syndromes, it does not typically have organ involvement or lead to other health concerns.

ResearchLimited published research (7 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for episodic angioedema with eosinophilia.

7 publications have been identified in PubMed for episodic angioedema with eosinophilia. Research spans Other (29%), Basic Science / Preclinical (29%), and Epidemiology / Natural History (29%).

Recent Publications

Koreeda T (2025). [PMID: 40271157](https://pubmed.ncbi.nlm.nih.gov/40271157/). *J Allergy Clin Immunol Glob*. [Basic Science / Preclinical]
Anderson CF (2025). [PMID: 40350095](https://pubmed.ncbi.nlm.nih.gov/40350095/). *J Allergy Clin Immunol*. [Basic Science / Preclinical]
Atik Ö (2025). [PMID: 41486796](https://pubmed.ncbi.nlm.nih.gov/41486796/). *Tuberk Toraks*. [Epidemiology / Natural History]
Ledoult E (2024). [PMID: 39306790](https://pubmed.ncbi.nlm.nih.gov/39306790/). *J Allergy Clin Immunol*. [Other]
Dube A (2024). [PMID: 39301376](https://pubmed.ncbi.nlm.nih.gov/39301376/). *Cureus*. [Case Report / Case Series]

Data assembled from 2 of 12 sources · Last updated Sep 18, 2026, 11:35 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:13029

Questions for Your Care Team

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episodic angioedema with eosinophilia

Overview

Research Landscape

Recent Publications

Medical References

External Resources

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team