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A severe, sometimes life-threatening, form of erythema multiforme. It is considered to be a hypersensitivity skin reaction triggered by a variety of stimuli, including infections and medication. It is characterized by raised, edematous papules in the extremities; involvement of one or more mucous membranes; and epidermal detachment involving less than ten percent of the total body surface area.
Biomarker and diagnostic research for erythema multiforme major has been reported in the published literature.
1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
20 publications have been identified in PubMed for erythema multiforme major. Research spans Case Report / Case Series (70%), Other (15%), and Diagnostic / Biomarker (5%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 14 | 70% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 8:50 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Other research |
3 |
15% |
Testing and diagnosis research | 1 | 5% |
Clinical study results | 1 | 5% |
Laboratory research | 1 | 5% |
Hafsi W (2026). [PMID: 29261983](https://pubmed.ncbi.nlm.nih.gov/29261983/). *Unknown Journal*. [Other]
Lang Houser M (2026). [PMID: 41298285](https://pubmed.ncbi.nlm.nih.gov/41298285/). *Journal of cutaneous pathology*. [Case Report / Case Series]
Mo S (2026). [PMID: 41746840](https://pubmed.ncbi.nlm.nih.gov/41746840/). *Clin Exp Dermatol*. [Case Report / Case Series]
Oakley AM (2026). [PMID: 29083827](https://pubmed.ncbi.nlm.nih.gov/29083827/). *Unknown Journal*. [Other]
Alicea PA (2025). [PMID: 40625470](https://pubmed.ncbi.nlm.nih.gov/40625470/). *Cureus*. [Clinical Trial Publication]
Passby L (2025). [PMID: 41340545](https://pubmed.ncbi.nlm.nih.gov/41340545/). *Clinical and experimental dermatology*. [Case Report / Case Series]
Shajil C (2025). [PMID: 40125040](https://pubmed.ncbi.nlm.nih.gov/40125040/). *Indian dermatology online journal*. [Case Report / Case Series]
Caputo V (2025). [PMID: 40047373](https://pubmed.ncbi.nlm.nih.gov/40047373/). *Italian journal of dermatology and venereology*. [Case Report / Case Series]
Silva KRPD (2025). [PMID: 40531783](https://pubmed.ncbi.nlm.nih.gov/40531783/). *Einstein (Sao Paulo)*. [Case Report / Case Series]
Nadeem A (2025). [PMID: 41209896](https://pubmed.ncbi.nlm.nih.gov/41209896/). *Cureus*. [Case Report / Case Series]