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toxic epidermal necrolysis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

toxic epidermal necrolysis

MONDO:0019810

Also known as:SJS-TENTENtoxic epidermolysis

Find Clinical TrialsTrials

Overview

Toxic epidermal necrolysis (TEN) is an acute and severe skin disease with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes.

Clinical Trials6 registered · 3 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fever, Abnormal blistering of the skin, Inflammatory abnormality of the skin, and Fatigue and others; and common findings: Elevated circulating hepatic transaminase concentration, Myalgia, Rhinitis, and Cough and others. 64 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	11	Genital blistering, Skin ulcer, Oral mucosal blisters

Diagnosis

Biomarker and diagnostic research for toxic epidermal necrolysis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 5 very common features, 22 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 3 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE2, 3 PHASE1, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04711200](https://clinicaltrials.gov/study/NCT04711200)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:54 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:95455

GARD

Genetic and Rare Diseases Info Center

GARD:7743

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	82	38%
Patient case studies	58	27%
Disease patterns and progression	41	19%
Other research	12	6%
Laboratory research	9	4%
Clinical study results	7	3%
Testing and diagnosis research	6	3%
New treatment approaches	2	1%

Kisho

toxic epidermal necrolysis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Five-Year Experience at a Tertiary Referral Hospital in Somalia.

Epidermal necrolysis sequelae: A cohort study on prevalence and risk factors.

Ocular involvement in toxic epidermal necrolysis syndrome at Chelsea and Westminster Hospital: a 10-year retrospective analysis and review of current literature.

toxic epidermal necrolysis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Five-Year Experience at a Tertiary Referral Hospital in Somalia.

Epidermal necrolysis sequelae: A cohort study on prevalence and risk factors.

Ocular involvement in toxic epidermal necrolysis syndrome at Chelsea and Westminster Hospital: a 10-year retrospective analysis and review of current literature.