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Familial progressive hyperpigmentation is a rare, genetic, skin pigmentation anomaly disorder characterized by irregular patches of hyperpigmented skin which present at birth or in early infancy and increase in size, number and confluence with age. Affected areas of the body include the face, neck, trunk and limbs, as well as the palms, soles, oral mucosa and conjuctiva. No hypogmentation macules are observed and no systemic diseases are associated.
Features include: Hyperpigmentation of the skin.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 1 | Hyperpigmentation of the skin |
No clinical trials have been registered for familial progressive hyperpigmentation.
9 publications have been identified in PubMed for familial progressive hyperpigmentation. Research spans Case Report / Case Series (56%), Other (11%), and Review / Meta-Analysis (11%).
Wu B (2026). [PMID: 41779177](https://pubmed.ncbi.nlm.nih.gov/41779177/). *Mol Genet Genomics*. [Gene Therapy / Novel Therapeutics]
Huang X (2026). [PMID: 39152874](https://pubmed.ncbi.nlm.nih.gov/39152874/). *Indian J Dermatol Venereol Leprol*. [Other]
Gorssen W (2026). [PMID: 41882519](https://pubmed.ncbi.nlm.nih.gov/41882519/). *Genet Sel Evol*. [Basic Science / Preclinical]
Okamura K (2026). [PMID: 41127964](https://pubmed.ncbi.nlm.nih.gov/41127964/). *J Dermatol*. [Review / Meta-Analysis]
Hida T (2025). [PMID: 39269165](https://pubmed.ncbi.nlm.nih.gov/39269165/). *J Dermatol*. [Case Report / Case Series]
Gaurav V (2025). [PMID: 40125039](https://pubmed.ncbi.nlm.nih.gov/40125039/). *Indian Dermatol Online J*. [Case Report / Case Series]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Untaaveesup S (2025). [PMID: 40792575](https://pubmed.ncbi.nlm.nih.gov/40792575/). *Acta Derm Venereol*. [Case Report / Case Series]
Kanchanasutthiyakorn S (2025). [PMID: 40589716](https://pubmed.ncbi.nlm.nih.gov/40589716/). *Biomed Rep*. [Case Report / Case Series]
Wang T (2025). [PMID: 40115815](https://pubmed.ncbi.nlm.nih.gov/40115815/). *Front Genet*. [Case Report / Case Series]
AI-curated news mentioning familial progressive hyperpigmentation
Updated Jun 3, 2026
A new study outlines practical therapeutic strategies for managing acne-induced hyperpigmentation across various skin types. The findings aim to enhance treatment approaches for this common skin condition.